STUDY OF BENZODIAZEPINE LIKE EFFECT OF MATRICARIA RECUTITA EXTRACT ON ACUTE PAIN IN THE PRESENCE AND ABSENCE OF PARAGIGANTOCELLULARIS NUCLEUS IN ADULT MALE RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ABBASIZADEH Z.; KESMATI M.; FATHI MOGHADAM H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Physiology and Pharmacology Year:2006 | Volume:10 | Issue:3 Page(s): 183-189

Download Full-Text

Persian Verion

View:

870

Download:

Cites:

Information Journal Paper

Title

STUDY OF BENZODIAZEPINE LIKE EFFECT OF MATRICARIA RECUTITA EXTRACT ON ACUTE PAIN IN THE PRESENCE AND ABSENCE OF PARAGIGANTOCELLULARIS NUCLEUS IN ADULT MALE RATS

Author(s)

ABBASIZADEH Z. | KESMATI M. | FATHI MOGHADAM H. | Issue Writer Certificate

Keywords

MATRICARIA RECUTITAQ3

PARAGIGANTOCELLULARIS NUCLEUSQ2

FLUMAZENILQ3

HOT PLATEQ3

Abstract

Introduction: In this study the effect of MATRICARIA RECUTITA extract on acute pain in the presence and absence of FLUMAZENIL (antagonist of benzodiazepine) and lesioned paragigantocellularis (PGi) nucleus was investigated.Method: Wistar male rats (250±20 g) were used. Animals were grouped randomly into intact, sham and bilateral lesion of PGi nucleus. Intact and lesioned animals, each divided into 4 subgroups which received saline, M. recutita hydro-alcoholic extract (25 mg/kg), FLUMAZENIL (1 mg/kg) and FLUMAZENIL + M. recutita. HOT PLATE test were used for pain thereshold evaluation.Results: Results showed that: In intact animals M. recutita induced analgesic effect but FLUMAZENIL had significant hyperalgesic effect. In these animals FLUMAZENIL prevented the analgesic effects of M. recutita. Lesion of PGi induced significant hyperalgesia. M. recutita in absence of PGi nucleus showed significant analgesic effect and FLUMAZENIL increased pain sensation and caused significant hyperalgesia. The analgesic effect of M. recutita attenuated by FLUMAZENIL in absence of PGi nucleus.Conclusion: It seems that PGi nucleus involves in pain modulation but analgesic effect of M. recutita that may be via the benzodiazepine-like activity of some its components does not interact with PGi nucleus.

Cites

No record.

References

Cite

APA: Copy

ABBASIZADEH, Z., KESMATI, M., & FATHI MOGHADAM, H.. (2006). STUDY OF BENZODIAZEPINE LIKE EFFECT OF MATRICARIA RECUTITA EXTRACT ON ACUTE PAIN IN THE PRESENCE AND ABSENCE OF PARAGIGANTOCELLULARIS NUCLEUS IN ADULT MALE RATS. PHYSIOLOGY AND PHARMACOLOGY, 10(3), 183-189. SID. https://sid.ir/paper/75069/en

Vancouver: Copy

ABBASIZADEH Z., KESMATI M., FATHI MOGHADAM H.. STUDY OF BENZODIAZEPINE LIKE EFFECT OF MATRICARIA RECUTITA EXTRACT ON ACUTE PAIN IN THE PRESENCE AND ABSENCE OF PARAGIGANTOCELLULARIS NUCLEUS IN ADULT MALE RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2006;10(3):183-189. Available from: https://sid.ir/paper/75069/en

IEEE: Copy

Z. ABBASIZADEH, M. KESMATI, and H. FATHI MOGHADAM, “STUDY OF BENZODIAZEPINE LIKE EFFECT OF MATRICARIA RECUTITA EXTRACT ON ACUTE PAIN IN THE PRESENCE AND ABSENCE OF PARAGIGANTOCELLULARIS NUCLEUS IN ADULT MALE RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 10, no. 3, pp. 183–189, 2006, [Online]. Available: https://sid.ir/paper/75069/en

Related Journal Papers