STUDY OF BENZODIAZEPINE LIKE EFFECT OF MATRICARIA RECUTITA EXTRACT ON ACUTE PAIN IN THE PRESENCE AND ABSENCE OF PARAGIGANTOCELLULARIS NUCLEUS IN ADULT MALE RATS

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ABBASIZADEH Z.; KESMATI M.; FATHI MOGHADAM H.

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Journal: Physiology and Pharmacology Year:2006 | Volume:10 | Issue:3 Page(s): 183-189

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Title

STUDY OF BENZODIAZEPINE LIKE EFFECT OF MATRICARIA RECUTITA EXTRACT ON ACUTE PAIN IN THE PRESENCE AND ABSENCE OF PARAGIGANTOCELLULARIS NUCLEUS IN ADULT MALE RATS

Author(s)

ABBASIZADEH Z. | KESMATI M. | FATHI MOGHADAM H. | Issue Writer Certificate

Keywords

MATRICARIA RECUTITAQ3

PARAGIGANTOCELLULARIS NUCLEUSQ2

FLUMAZENILQ3

HOT PLATEQ3

Abstract

Introduction: In this study the effect of MATRICARIA RECUTITA extract on acute pain in the presence and absence of FLUMAZENIL (antagonist of benzodiazepine) and lesioned paragigantocellularis (PGi) nucleus was investigated.Method: Wistar male rats (250±20 g) were used. Animals were grouped randomly into intact, sham and bilateral lesion of PGi nucleus. Intact and lesioned animals, each divided into 4 subgroups which received saline, M. recutita hydro-alcoholic extract (25 mg/kg), FLUMAZENIL (1 mg/kg) and FLUMAZENIL + M. recutita. HOT PLATE test were used for pain thereshold evaluation.Results: Results showed that: In intact animals M. recutita induced analgesic effect but FLUMAZENIL had significant hyperalgesic effect. In these animals FLUMAZENIL prevented the analgesic effects of M. recutita. Lesion of PGi induced significant hyperalgesia. M. recutita in absence of PGi nucleus showed significant analgesic effect and FLUMAZENIL increased pain sensation and caused significant hyperalgesia. The analgesic effect of M. recutita attenuated by FLUMAZENIL in absence of PGi nucleus.Conclusion: It seems that PGi nucleus involves in pain modulation but analgesic effect of M. recutita that may be via the benzodiazepine-like activity of some its components does not interact with PGi nucleus.

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APA: Copy

ABBASIZADEH, Z., KESMATI, M., & FATHI MOGHADAM, H.. (2006). STUDY OF BENZODIAZEPINE LIKE EFFECT OF MATRICARIA RECUTITA EXTRACT ON ACUTE PAIN IN THE PRESENCE AND ABSENCE OF PARAGIGANTOCELLULARIS NUCLEUS IN ADULT MALE RATS. PHYSIOLOGY AND PHARMACOLOGY, 10(3), 183-189. SID. https://sid.ir/paper/75069/en

Vancouver: Copy

ABBASIZADEH Z., KESMATI M., FATHI MOGHADAM H.. STUDY OF BENZODIAZEPINE LIKE EFFECT OF MATRICARIA RECUTITA EXTRACT ON ACUTE PAIN IN THE PRESENCE AND ABSENCE OF PARAGIGANTOCELLULARIS NUCLEUS IN ADULT MALE RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2006;10(3):183-189. Available from: https://sid.ir/paper/75069/en

IEEE: Copy

Z. ABBASIZADEH, M. KESMATI, and H. FATHI MOGHADAM, “STUDY OF BENZODIAZEPINE LIKE EFFECT OF MATRICARIA RECUTITA EXTRACT ON ACUTE PAIN IN THE PRESENCE AND ABSENCE OF PARAGIGANTOCELLULARIS NUCLEUS IN ADULT MALE RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 10, no. 3, pp. 183–189, 2006, [Online]. Available: https://sid.ir/paper/75069/en

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