ANALGESIC EFFECT OF FLOWER AND LEAF EXTRACTS OF TANACETUM PARTHENIUM USING
FORMALIN TEST IN MICE

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FEREYDOUNI M.; ETEMADI L.; BOROUK A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Paper Information

Journal: Physiology and Pharmacology Year:2002 | Volume:5 | Issue:2 Page(s): 189-198

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Information Journal Paper

Title

ANALGESIC EFFECT OF FLOWER AND LEAF EXTRACTS OF TANACETUM PARTHENIUM USING FORMALIN TEST IN MICE

Author(s)

FEREYDOUNI M. | ETEMADI L. | BOROUK A. | Issue Writer Certificate

Keywords

TANACETUM PARTHENIUMQ4

MICEQ3

FORMALIN TESTQ3

MEDICINAL PLANTSQ3

ANALGESIC EFFECTQ4

Abstract

In the present study the possible ANALGESIC EFFECT of flower (with 44.6% humidity) and leaf (with 40% humidity) extracts of TANACETUM PARTHENIUM was investigated.For this purpose, FORMALIN TEST (chronic pain model) was used and sodium salisylate (SS; 200 mg/Kg; i.p.) was used as positive control and the effect of extracts at doses of 10, 25, and 50 mg/Kg (i.p.) were evaluated. The results showed that extracts can decrease pain in both phases of FORMALIN TEST, especially in the first phase and sodium salisylate can decrease pain significantly in second phase of the test (P<0.01). These effects were also observed for minimal doses of the extracts (P<0.01). The minimum lethal dose of the extracts is estimated about 4000 mg/Kg for the flower extract and 3000 mg/Kg for the leaf extract.It has been reported that these extracts like SS have an inhibitory effect on prostaglandin synthesis. Because the extracts have analgesic properties in both phases of FORMALIN TEST compared to SS which was only effective in the second phase, it may be suggested that the extracts are engaged in both central and peripheral analgesic mechanisms.

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APA: Copy

FEREYDOUNI, M., ETEMADI, L., & BOROUK, A.. (2002). ANALGESIC EFFECT OF FLOWER AND LEAF EXTRACTS OF TANACETUM PARTHENIUM USING FORMALIN TEST IN MICE. PHYSIOLOGY AND PHARMACOLOGY, 5(2), 189-198. SID. https://sid.ir/paper/74982/en

Vancouver: Copy

FEREYDOUNI M., ETEMADI L., BOROUK A.. ANALGESIC EFFECT OF FLOWER AND LEAF EXTRACTS OF TANACETUM PARTHENIUM USING FORMALIN TEST IN MICE. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2002;5(2):189-198. Available from: https://sid.ir/paper/74982/en

IEEE: Copy

M. FEREYDOUNI, L. ETEMADI, and A. BOROUK, “ANALGESIC EFFECT OF FLOWER AND LEAF EXTRACTS OF TANACETUM PARTHENIUM USING FORMALIN TEST IN MICE,” PHYSIOLOGY AND PHARMACOLOGY, vol. 5, no. 2, pp. 189–198, 2002, [Online]. Available: https://sid.ir/paper/74982/en

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