EVALUATION OF UCP2 EXPRESSION IN THE PHENOMENON OF ISCHEMIC RESISTANCE INDUCED BY ALTERNATING NORMOBARIC HYPEROXIA IN A RAT MODEL OF STROKE

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ALAVIAN FIROOZEH; HAJIZADEH SOHRAB; BIGDELI MOHAMMAD REZA; BAYAT GHOLAMREZA; JAVAN MOHAMMAD

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Journal: Physiology and Pharmacology Year:2012 | Volume:16 | Issue:1 Page(s): 54-61

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Title

EVALUATION OF UCP2 EXPRESSION IN THE PHENOMENON OF ISCHEMIC RESISTANCE INDUCED BY ALTERNATING NORMOBARIC HYPEROXIA IN A RAT MODEL OF STROKE

Author(s)

Keywords

HYPEROXIAQ3

STROKEQ3

PRECONDITIONINGQ3

UCP2Q2

Abstract

Introduction: ischemic PRECONDITIONING is one of the most important mechanisms, responsible for the increased brain resistance after STROKE. One of the most important candidates to ischemia PRECONDITIONING is intermittent normobaric HYPEROXIA. In this study, the effect of intermittent normobaric HYPEROXIA on the expression of UCP2 was investigated in a STROKE model.Methods: Rats were divided into 4 groups (normoxia – sham, HYPEROXIA – sham, normoxia – STROKE and HYPEROXIA – STROKE). HYPEROXIA groups were exposed to 95% inspired O2, for 4 h/day and 6 consecutive days. Oxygen level in the control groups was %21 (normoxia). After 24 h, STROKE groups were subjected to 60 min of right middle cerebral artery occlusion. After 24 h reperfusion neurological deficit scores were assessed. The brain UCP2 levels were analyzed by western blot.Results: The results of this study showed that following brain ischemia-reperfusion, UCP2 levels significantlyincreased in the STROKE groups compared with the sham group; while there was no significant difference in HYPEROXIA groups compared with normoxia. Also HYPEROXIA decreased neurological deficit scores.Conclusion: Following ischemia, oxidative stress caused by increase of ROS, leads to increased UCP2 levels in STROKE groups. In this study, the neuroprotective effect of HYPEROXIA is independent of UCP2 expression.

Cites

EFFECTS OF PRECONDITIONING WITH INTERMITTENT NORMOBARIC HYPEROXIA ON TNFR1 AND TNFR2 EXPRESSION IN THE RAT BRAIN

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APA: Copy

ALAVIAN, FIROOZEH, HAJIZADEH, SOHRAB, BIGDELI, MOHAMMAD REZA, BAYAT, GHOLAMREZA, & JAVAN, MOHAMMAD. (2012). EVALUATION OF UCP2 EXPRESSION IN THE PHENOMENON OF ISCHEMIC RESISTANCE INDUCED BY ALTERNATING NORMOBARIC HYPEROXIA IN A RAT MODEL OF STROKE. PHYSIOLOGY AND PHARMACOLOGY, 16(1), 54-61. SID. https://sid.ir/paper/75095/en

Vancouver: Copy

ALAVIAN FIROOZEH, HAJIZADEH SOHRAB, BIGDELI MOHAMMAD REZA, BAYAT GHOLAMREZA, JAVAN MOHAMMAD. EVALUATION OF UCP2 EXPRESSION IN THE PHENOMENON OF ISCHEMIC RESISTANCE INDUCED BY ALTERNATING NORMOBARIC HYPEROXIA IN A RAT MODEL OF STROKE. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2012;16(1):54-61. Available from: https://sid.ir/paper/75095/en

IEEE: Copy

FIROOZEH ALAVIAN, SOHRAB HAJIZADEH, MOHAMMAD REZA BIGDELI, GHOLAMREZA BAYAT, and MOHAMMAD JAVAN, “EVALUATION OF UCP2 EXPRESSION IN THE PHENOMENON OF ISCHEMIC RESISTANCE INDUCED BY ALTERNATING NORMOBARIC HYPEROXIA IN A RAT MODEL OF STROKE,” PHYSIOLOGY AND PHARMACOLOGY, vol. 16, no. 1, pp. 54–61, 2012, [Online]. Available: https://sid.ir/paper/75095/en

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