KETAMINE INDUCES ANTEROGRADE AND RETROGRADE AMNESIA IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NEDAEI S.E.; POURMOTEABED A.; MEHRABINASAB E.; TOUHIDI ATEFEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Physiology and Pharmacology Year:2009 | Volume:12 | Issue:4 Page(s): 328-335

Download Full-Text

Persian Verion

View:

1,214

Download:

Cites:

Information Journal Paper

Title

KETAMINE INDUCES ANTEROGRADE AND RETROGRADE AMNESIA IN RATS

Author(s)

NEDAEI S.E. | POURMOTEABED A. | MEHRABINASAB E. | TOUHIDI ATEFEH | Issue Writer Certificate

Keywords

KETAMINEQ3

ANTEROGRADE AMNESIAQ3

RETROGRADE AMNESIAQ3

MORRIS WATER MAZEQ3

RATQ3

Abstract

Introduction: The N-methyl-D-aspartate (NMDA) receptors, which have been implicated in memory formation, could be noncompetitively blocked by KETAMINE. The present study examines the short term effect of KETAMINE on induction of anterograde and RETROGRADE AMNESIA in male RATs using MORRIS WATER MAZE (MWM). Methods: Male N-MRI RATs were randomly divided into nine experimental groups. MWM studies were performed to evaluate spatial learning and memory parameters. In order to examine the effect of KETAMINE on the induction of ANTEROGRADE AMNESIA, 4 groups of animals received daily injections ofKETAMINE (1, 3, 6 or 12 mg/kg, i.p.) 10 min before testing on training days. To examine the effect of drug on the induction of RETROGRADE AMNESIA four other groups of RATs received daily injection of normal saline (on training days) and KETAMINE (1, 3, 6, or 12 mg/kg, i.p.) (in probe trial) 10 min before testing. RATs of the control group received normal saline on all days of experiments. Spatial learning and memory parameters were recorded and subjected to the analysis of variance (ANOVA). Difference was considered significant if p<0.05.Results: Data showed that injection of ketarnine at the dose of 3 mg/kg and higher inhibits spatial learning and memory parameters and induces both anterograde and RETROGRADE AMNESIA in RATs.Conclusion: It seems that ketarnine induces inhibitory effects on spatial learning and memory via blocking the NMDA receptors. On the other hand, KETAMINE induced dose dependent decrease in swim speed which was significant at the dose of 12 mg/kg.

Cites

No record.

References

No record.

Cite

APA: Copy

NEDAEI, S.E., POURMOTEABED, A., MEHRABINASAB, E., & TOUHIDI, ATEFEH. (2009). KETAMINE INDUCES ANTEROGRADE AND RETROGRADE AMNESIA IN RATS. PHYSIOLOGY AND PHARMACOLOGY, 12(4), 328-335. SID. https://sid.ir/paper/75129/en

Vancouver: Copy

NEDAEI S.E., POURMOTEABED A., MEHRABINASAB E., TOUHIDI ATEFEH. KETAMINE INDUCES ANTEROGRADE AND RETROGRADE AMNESIA IN RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2009;12(4):328-335. Available from: https://sid.ir/paper/75129/en

IEEE: Copy

S.E. NEDAEI, A. POURMOTEABED, E. MEHRABINASAB, and ATEFEH TOUHIDI, “KETAMINE INDUCES ANTEROGRADE AND RETROGRADE AMNESIA IN RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 12, no. 4, pp. 328–335, 2009, [Online]. Available: https://sid.ir/paper/75129/en

Related Journal Papers