INVESTIGATION ON THE VASODILATORY EFFECT OF INSULIN THROUGH KATP CHANNELS AND NO PATHWAY IN THE SKIN VESSELS OF NATIVE AND DIABETIC RATS

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BARABADI Z.; HAJIZADEH S.; JAVAN MOHAMMAD; ERFANI B.; HEYDARIANPOUR A.

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Journal: Physiology and Pharmacology Year:2008 | Volume:11 | Issue:4 Page(s): 270-275

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Title

INVESTIGATION ON THE VASODILATORY EFFECT OF INSULIN THROUGH KATP CHANNELS AND NO PATHWAY IN THE SKIN VESSELS OF NATIVE AND DIABETIC RATS

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Keywords

INSULINQ3

DIABETESQ2

SKIN BLOOD FLOWQ3

NOQ3

KATP CHANNELSQ3

Abstract

Introduction: Endothelium and smooth muscle dysfunction are the most important complications of DIABETES. In type 1 diabetic patients, absence of INSULIN leads to vasoconstriction and lower skin blood perfusion. Release of some mediators by endothelium which is induced by INSULIN causes vasodilation, but the exact mechanism of INSULIN vasodilatory effect is NOt detected properly. At present study we investigated the role of NO as a vasodilator and KATP CHANNELS and their interaction in the vasodilatory effect of INSULIN on the skin vessels.Methods: Male Wistar rats (200-250 g) were made diabetic by streptozocin (50 mg/kg, s.c). After 40 days of DIABETES induction, SKIN BLOOD FLOW was measured by Laser Doppler Flowmetry (LDF) technique. INSULIN, LNNA (NO blocker) and Glibenclamide (KATP blocker) infusion were subcutaneously made by infusion pump. Results: INSULIN increased SKIN BLOOD FLOW in both control and diabetic groups and this increase was significantly higher in diabetic group. INSULIN vasodilatory effect was decreased by LNNA and Glibenclamide. Simultaneous block of both NO and KATP was more effective.Conclusion: INSULIN induces vasodilation in part by NO release and partly by activation of K ATP channels. However some interaction has been reported between these two pathways. Since by block of these routes blood flow has NOt been completely inhibited, other factors may be involved in this effect and yet to be elucidated.

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APA: Copy

BARABADI, Z., HAJIZADEH, S., JAVAN, MOHAMMAD, ERFANI, B., & HEYDARIANPOUR, A.. (2008). INVESTIGATION ON THE VASODILATORY EFFECT OF INSULIN THROUGH KATP CHANNELS AND NO PATHWAY IN THE SKIN VESSELS OF NATIVE AND DIABETIC RATS. PHYSIOLOGY AND PHARMACOLOGY, 11(4), 270-275. SID. https://sid.ir/paper/75141/en

Vancouver: Copy

BARABADI Z., HAJIZADEH S., JAVAN MOHAMMAD, ERFANI B., HEYDARIANPOUR A.. INVESTIGATION ON THE VASODILATORY EFFECT OF INSULIN THROUGH KATP CHANNELS AND NO PATHWAY IN THE SKIN VESSELS OF NATIVE AND DIABETIC RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2008;11(4):270-275. Available from: https://sid.ir/paper/75141/en

IEEE: Copy

Z. BARABADI, S. HAJIZADEH, MOHAMMAD JAVAN, B. ERFANI, and A. HEYDARIANPOUR, “INVESTIGATION ON THE VASODILATORY EFFECT OF INSULIN THROUGH KATP CHANNELS AND NO PATHWAY IN THE SKIN VESSELS OF NATIVE AND DIABETIC RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 11, no. 4, pp. 270–275, 2008, [Online]. Available: https://sid.ir/paper/75141/en

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