EFFECT OF FORCED TREADMILL EXERCISE ON LONG-TERM POTENTIATION (LTP) IN THE DENTATE GYRUS OF HIPPOCAMPUS IN MALE RATS

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BABRI SH.; RAEISI P.; ALAEI H.A.; SHARIFI M.R.; MOHADES G.

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Journal: Physiology and Pharmacology Year:2008 | Volume:12 | Issue:1 Page(s): 39-45

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Title

EFFECT OF FORCED TREADMILL EXERCISE ON LONG-TERM POTENTIATION (LTP) IN THE DENTATE GYRUS OF HIPPOCAMPUS IN MALE RATS

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Keywords

LONG-TERM POTENTIATIONQ3

PHYSICAL ACTIVITYQ2

TREADMILL EXERCISEQ3

LEARNING AND MEMORYQ3

Abstract

Introduction: Previous studies have shown that exercise affects cognitive function. Considering that exercise in anima] studies can be either voluntary or forced, effects of exercise (specially forced exercise) on LEARNING AND MEMORY remains a matter of controversy. The present study aimed to investigate the effects of TREADMILL EXERCISE on LTP in the dentate gyrus of rats.Methods: A moderate exercise program was used consisting of treadmill running at 17 m/min and O-degree inclination for 40 min/day, 7 days/week, for duration of 12 weeks. Field excitatory postsynaptic potentials (fEPSP) were recorded in dentate gyrus (DG) after stimulation of Perforant pathway by 400 Hz titanization.Results: The indices of responses including the amplitude of population spike and the slope of excitatory postsynaptic potential were significantly smaller in the exercise group with respect to the control group. But the stimulus-response curves in DG area measured before induction of LTP, showed no significant difference between the groups.Conclusion: The present results suggest that alternative stress due to electrical shock in order to motivate the animal to run in TREADMILL EXERCISE affects synaptic transmission and impairs LTP induction in DG. Therefore, these experiments indicate that chronic TREADMILL EXERCISE can decline LEARNING AND MEMORY.

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APA: Copy

BABRI, SH., RAEISI, P., ALAEI, H.A., SHARIFI, M.R., & MOHADES, G.. (2008). EFFECT OF FORCED TREADMILL EXERCISE ON LONG-TERM POTENTIATION (LTP) IN THE DENTATE GYRUS OF HIPPOCAMPUS IN MALE RATS. PHYSIOLOGY AND PHARMACOLOGY, 12(1), 39-45. SID. https://sid.ir/paper/75263/en

Vancouver: Copy

BABRI SH., RAEISI P., ALAEI H.A., SHARIFI M.R., MOHADES G.. EFFECT OF FORCED TREADMILL EXERCISE ON LONG-TERM POTENTIATION (LTP) IN THE DENTATE GYRUS OF HIPPOCAMPUS IN MALE RATS. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2008;12(1):39-45. Available from: https://sid.ir/paper/75263/en

IEEE: Copy

SH. BABRI, P. RAEISI, H.A. ALAEI, M.R. SHARIFI, and G. MOHADES, “EFFECT OF FORCED TREADMILL EXERCISE ON LONG-TERM POTENTIATION (LTP) IN THE DENTATE GYRUS OF HIPPOCAMPUS IN MALE RATS,” PHYSIOLOGY AND PHARMACOLOGY, vol. 12, no. 1, pp. 39–45, 2008, [Online]. Available: https://sid.ir/paper/75263/en

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