Preparation of modified magnetic nanoparticles for in vitro delivery of ceftriaxone

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ALIPOUR ARASH; TEHRANI MOHAMMAD SABER; ABEROOMAND AZAR PARVIZ; GIVIANRAD MOHAMMAD HADI

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Journal Paper

Paper Information

Journal: NANOMEDICINE RESEARCH JOURNAL Year:2019 | Volume:4 | Issue:2 Page(s): 84-90

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Title

Preparation of modified magnetic nanoparticles for in vitro delivery of ceftriaxone

Author(s)

ALIPOUR ARASH | TEHRANI MOHAMMAD SABER | ABEROOMAND AZAR PARVIZ | GIVIANRAD MOHAMMAD HADI | Issue Writer Certificate

Keywords

Ceftriaxone

Drug Delivery

Magnetic Nanoparticles

Abstract

The present study introduces a new approach for the surface radical grafting of n-vinylcaprolactam as a thermoresponsive agent and 3-allyloxy-1, 2-propandiol with an affinity toward Ceftriaxone onto modified Fe₃ O₄ nanoparticles by 3-mercaptopropyltrimethoxysilane. Characterization of the grafted nanoparticles was performed by Fourier Transform Infrared Spectroscopy, Elemental Analysis, and Vibrating Sample Magnetometer. The surface morphology was examined by Scanning Electron Microscopy. The obtained grafted nanoparticles were employed to determine trace Ceftriaxone in biological human fluids. Ceftriaxone uptake profile by the modified Magnetic Nanoparticles demonstrated that the active sites were well accessible in the grafted nano carrier. Results showed that the adsorption behavior was fittable by the Langmuir adsorption isotherm model. Moreover, our investigation included solid phase extraction for simulated human biological fluids (e. g., gastric and intestinal fluids). Recovery of extraction of human biological fluids was over 90% was achieved in the present research. Overall, Magnetic Nanoparticles coated with sensitive polymer have proved to enjoy unique properties in biotechnology and Drug Delivery research.

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References

Liquid chromatography– tandem mass spectrometry for the simultaneous quantitation of ceftriaxone, metronidazole and hydroxymetronidazole in plasma from seriously ill, severely malnourished children

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APA: Copy

ALIPOUR, ARASH, TEHRANI, MOHAMMAD SABER, ABEROOMAND AZAR, PARVIZ, & GIVIANRAD, MOHAMMAD HADI. (2019). Preparation of modified magnetic nanoparticles for in vitro delivery of ceftriaxone. NANOMEDICINE RESEARCH JOURNAL, 4(2), 84-90. SID. https://sid.ir/paper/753678/en

Vancouver: Copy

ALIPOUR ARASH, TEHRANI MOHAMMAD SABER, ABEROOMAND AZAR PARVIZ, GIVIANRAD MOHAMMAD HADI. Preparation of modified magnetic nanoparticles for in vitro delivery of ceftriaxone. NANOMEDICINE RESEARCH JOURNAL[Internet]. 2019;4(2):84-90. Available from: https://sid.ir/paper/753678/en

IEEE: Copy

ARASH ALIPOUR, MOHAMMAD SABER TEHRANI, PARVIZ ABEROOMAND AZAR, and MOHAMMAD HADI GIVIANRAD, “Preparation of modified magnetic nanoparticles for in vitro delivery of ceftriaxone,” NANOMEDICINE RESEARCH JOURNAL, vol. 4, no. 2, pp. 84–90, 2019, [Online]. Available: https://sid.ir/paper/753678/en

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