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Information Journal Paper

Title

Nephroprotective Eff ect of Nasturtium offi cinale (Watercress) Ethanol Extract and Vitamin E on Vancomycin-Induced Nephrotoxicity in Rats

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Abstract

 Background: Vancomycin (VCM) is an important antibiotic that is active against gram-positive cocci, and its Nephrotoxicity remain as a major problem in clinical use. Objectives: This study was designed to investigate the eff ect of Nasturtium offi cinale hydro-alcoholic extract (NOE) and Vitamin E aganist VCM-induced Nephrotoxicity in adult male wistar Rats. Methods: A total of 36 animals were randomly divided into 6 equal groups (n = 6) including 1, control group; 2, VCM group; 3, VCM + NOE (250 mg/kg) group; 4, VCM + NOE (500 mg/kg) group; 5, VCM + Vitamin E (250 mg/kg) group; and 6, VCM + Vitamin E (500 mg/kg) group. VCM (200 mg kg i. p. ) was given every 12 hours for 7 consecutive days. NOE and Vitamin E were orally given to Rats 30 minutes prior to i. p. injection of VCM. Acute renal failure was evaluated by measuring serum urea, creatinine levels, and creatinine clearance. Change in body weight and kidney weight (g/100 g body weight) were measured. The right kidney was fi xed in formalin for pathological evaluation and the left kidney was homogenized for determination of malondialdehyde (MDA). Results: VCM signifi cantly increased serum creatinine and urea levels, MDA levels, kidney weight/100 mg weight of body, as well as reduced creatinine clearance. NOE (250, 500 mg kg-1 ) and Vitamin E (500 mg kg-1) pretreatment considerably alleviated all of these changes when compared with VCM treated alone. Histological examination of VCM-treated group showed a marked renal injury with tubular epithelial cell desquamation, swelling, and tubular dilatation. These changes were mitigated with NOE-and Vitamin E. Conclusions: The data indicate that NOE obviously attenuated VCM-induced Nephrotoxicity. Elucidation of the exact mechanism(s) of this protection requires more research, however, it might be mediated by antioxidant eff ects of NOE.

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    APA: Copy

    KARAMI, MASOMEH, MOSTAFAZADEH, MOSTAFA, SADEGHI, HOSSEIN, SADEGHI, HEIBATOLLAH, MEHRABAN, FOAD, Panahi Kokhdan, Esmaeel, SAYAHI, MOSLEM, & ABTAHI, SEYED REZA. (2018). Nephroprotective Eff ect of Nasturtium offi cinale (Watercress) Ethanol Extract and Vitamin E on Vancomycin-Induced Nephrotoxicity in Rats. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS, 13(1), 0-0. SID. https://sid.ir/paper/755393/en

    Vancouver: Copy

    KARAMI MASOMEH, MOSTAFAZADEH MOSTAFA, SADEGHI HOSSEIN, SADEGHI HEIBATOLLAH, MEHRABAN FOAD, Panahi Kokhdan Esmaeel, SAYAHI MOSLEM, ABTAHI SEYED REZA. Nephroprotective Eff ect of Nasturtium offi cinale (Watercress) Ethanol Extract and Vitamin E on Vancomycin-Induced Nephrotoxicity in Rats. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS[Internet]. 2018;13(1):0-0. Available from: https://sid.ir/paper/755393/en

    IEEE: Copy

    MASOMEH KARAMI, MOSTAFA MOSTAFAZADEH, HOSSEIN SADEGHI, HEIBATOLLAH SADEGHI, FOAD MEHRABAN, Esmaeel Panahi Kokhdan, MOSLEM SAYAHI, and SEYED REZA ABTAHI, “Nephroprotective Eff ect of Nasturtium offi cinale (Watercress) Ethanol Extract and Vitamin E on Vancomycin-Induced Nephrotoxicity in Rats,” JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS, vol. 13, no. 1, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/755393/en

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