The metabolome profiling of obese and non-obese individuals: Metabolically healthy obese and unhealthy non-obese paradox

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Chashmniam Saeed; HASHEMI MADANI NAHID; Nobakht Mothlagh Ghoochani BiBi Fatemeh; SAFARI ALIGHIARLOO NAHID; KHAMSEH MOHAMMAD E.

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Journal: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES Year:2020 | Volume:23 | Issue:2 Page(s): 186-194

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Title

The metabolome profiling of obese and non-obese individuals: Metabolically healthy obese and unhealthy non-obese paradox

Author(s)

Keywords

Metabolically healthy obese

Metabolically unhealthynon-obese

Metabolomics

Obesity

1H-NMR

Abstract

Objective(s): The molecular basis of “ metabolically healthy obese” and “ metabolically unhealthy nonobese” phenotypes is not fully understood. Our objective was to identify metabolite patterns differing in obese (metabolically healthy vs unhealthy (MHO vs MUHO)) and non-obese (metabolically healthy vs unhealthy (MHNO vs MUHNO)) individuals. Materials and Methods: This case-control study was performed on 86 subjects stratified into four groups using anthropometric and clinical measurements: MHO (21), MUHO (21), MHNO (22), and MUHNO (22). Serum metabolites were profiled using nuclear magnetic resonance (NMR). Multivariate analysis was applied to uncover discriminant metabolites, and enrichment analysis was performed to identify underlying pathways. Results: Significantly higher levels of glutamine, asparagine, alanine, L-glutathione reduced, 2-aminobutyrate, taurine, betaine, and choline, and lower level of D-sphingosine were observed in MHO group compared with MUHO. In comparison of MHNO and MUHNO groups, significantly lower levels of alanine, glycine, glutamine, histidine, L-glutathione reduced, and betaine, and higher levels of isoleucine, L-proline, cholic acid, and carnitine appeared in MUHNO individuals. Moreover, significantly affected pathways included amino acid metabolism, urea cycle and ammonia recycling in MUHO subjects and glutathione metabolism, amino acid metabolism, and ammonia recycling in MUHNO members. Conclusion: Literature review helped us to hint that altered levels of most metabolites might associate to insulin sensitivity and insulin resistance in MHO and MUHNO individuals, respectively. Besides, abnormal amino acid metabolism and ammonia recycling involved in unhealthy phenotypes (MUHO, MUHNO) might be associated with insulin resistance.

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APA: Copy

Chashmniam, Saeed, HASHEMI MADANI, NAHID, Nobakht Mothlagh Ghoochani, BiBi Fatemeh, SAFARI ALIGHIARLOO, NAHID, & KHAMSEH, MOHAMMAD E.. (2020). The metabolome profiling of obese and non-obese individuals: Metabolically healthy obese and unhealthy non-obese paradox. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 23(2), 186-194. SID. https://sid.ir/paper/756132/en

Vancouver: Copy

Chashmniam Saeed, HASHEMI MADANI NAHID, Nobakht Mothlagh Ghoochani BiBi Fatemeh, SAFARI ALIGHIARLOO NAHID, KHAMSEH MOHAMMAD E.. The metabolome profiling of obese and non-obese individuals: Metabolically healthy obese and unhealthy non-obese paradox. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2020;23(2):186-194. Available from: https://sid.ir/paper/756132/en

IEEE: Copy

Saeed Chashmniam, NAHID HASHEMI MADANI, BiBi Fatemeh Nobakht Mothlagh Ghoochani, NAHID SAFARI ALIGHIARLOO, and MOHAMMAD E. KHAMSEH, “The metabolome profiling of obese and non-obese individuals: Metabolically healthy obese and unhealthy non-obese paradox,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 23, no. 2, pp. 186–194, 2020, [Online]. Available: https://sid.ir/paper/756132/en

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