In vitro toxicological assessment of MgO and Silica Nanoparticle in human colon carcinoma cells

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GHORBANI SAMIRA; MOSHTAGHI HAMDOLLAH; SHEKARFOROUSH SEYED SHAHRAM; Ghaisari Hamid Reza; Sedaghati Fatemeh; ABBASVALI MARYAM

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Journal: NANOMEDICINE RESEARCH JOURNAL Year:2019 | Volume:4 | Issue:2 Page(s): 77-83

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Title

In vitro toxicological assessment of MgO and Silica Nanoparticle in human colon carcinoma cells

Author(s)

Keywords

Apoptosis

Cytotoxicity

HT-29 Cells

MgO Nanoparticles

Silica Nanoparticle

Abstract

The usage of nanoparticles (NPs) has been expanded to many fields such as agriculture, food industry, medicine and biotechnological fields. Therefore, human exposure to NPs is increasing continuously. Accordingly, their potential biological effect and toxicity of NPs for humans and the environment is still a topic of concern. This study aimed to investigate the Cytotoxicity effects of magnesium oxide (MgO) and silica (SiO2) NPs on human colon adenocarcinoma (HT-29) after 24 hours of exposure. In this study, Cytotoxicity of MgO and SiO2NPs was evaluated using MTT assay after 24 hours of MgO (50 nm) and SiO2 (90-110 nm) NP sexposure at doses of 25-200 μ g/ml. Moreover, to assess the rate of cell Apoptosis, cells were stained with ethidium bromide/acridineorange stain. The staining was examined under a fluorescent microscope. The exposure of HT29 cells to SiO2 and MgO NPs increased Cytotoxicity in a dose-dependent response. Also, these results revealed a significant increase in Apoptosis induction in groups treated with MgO and SiO2 NPs. These results showed that SiO2 and MgO NPs can cause Cytotoxicity in HT29 cells and it is better to avoid using them in foodstuff and food packaging ingredients.

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References

In vitro uptake and toxicity studies of metal nanoparticles and metal oxide nanoparticles in human HT29 cells

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APA: Copy

GHORBANI, SAMIRA, MOSHTAGHI, HAMDOLLAH, SHEKARFOROUSH, SEYED SHAHRAM, Ghaisari, Hamid Reza, Sedaghati, Fatemeh, & ABBASVALI, MARYAM. (2019). In vitro toxicological assessment of MgO and Silica Nanoparticle in human colon carcinoma cells. NANOMEDICINE RESEARCH JOURNAL, 4(2), 77-83. SID. https://sid.ir/paper/761010/en

Vancouver: Copy

GHORBANI SAMIRA, MOSHTAGHI HAMDOLLAH, SHEKARFOROUSH SEYED SHAHRAM, Ghaisari Hamid Reza, Sedaghati Fatemeh, ABBASVALI MARYAM. In vitro toxicological assessment of MgO and Silica Nanoparticle in human colon carcinoma cells. NANOMEDICINE RESEARCH JOURNAL[Internet]. 2019;4(2):77-83. Available from: https://sid.ir/paper/761010/en

IEEE: Copy

SAMIRA GHORBANI, HAMDOLLAH MOSHTAGHI, SEYED SHAHRAM SHEKARFOROUSH, Hamid Reza Ghaisari, Fatemeh Sedaghati, and MARYAM ABBASVALI, “In vitro toxicological assessment of MgO and Silica Nanoparticle in human colon carcinoma cells,” NANOMEDICINE RESEARCH JOURNAL, vol. 4, no. 2, pp. 77–83, 2019, [Online]. Available: https://sid.ir/paper/761010/en

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