THE EFFECTS OF AQUEOUS EXTRACTS OF MELISSA OFFICINAL IS ON WITHDRAWAL SYNDROME IN RATS

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MILADI GORJI H.; VAFAEI ABAS ALI; TAHERIAN ABAS ALI; VAEZI T.

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Paper Information

Journal: Scientific Journal of Kurdistan University of Medical Sciences Year:2008 | Volume:13 | Issue:2 (SERIAL NUMBER 48) Page(s): 27-33

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Title

THE EFFECTS OF AQUEOUS EXTRACTS OF MELISSA OFFICINAL IS ON WITHDRAWAL SYNDROME IN RATS

Author(s)

MILADI GORJI H. | VAFAEI ABAS ALI | TAHERIAN ABAS ALI | VAEZI T. | Issue Writer Certificate

Keywords

AQUEOUS DECOCTION EXTRACTSQ3

MELISSA OFFICINAL ISQ3

WITHDRAWAL SYNDROMEQ3

MORPHINEQ2

NALOXONEQ2

Abstract

Background and Aim: MELISSA OFFICINAL IS (MO) grows in the different parts of Iran abundantly. In previous studies, the extract of MO has been reported to have antinociceptive and anticonvulsive effects in rats. This study was designed to evaluate the effect of different doses of the AQUEOUS DECOCTION EXTRACTS of MO on WITHDRAWAL SYNDROME in rats.Material and Methods: 40 male albino rats (25-30 gr) were selected for this study. MORPHINE was used to produce drug dependency by Marshall Method (injection of 10 doses of drug in four days). 30 min before injection of NALOXONE (2 mg/kg), different doses of the extract (5, 10, 25 mg/kg) were injected intraperitoneally and saline (10ml/kg IP) was injected into the rats of control group. Assessment of classic WITHDRAWAL SYNDROME was based on the number of jumps and the weight of lecal material for every rat. Results: The results of this study indicated that injection of doses of 10, 25 mg/kg of the extract led to a significant decrease in the number of Jumps (p=0.005) and also in the weight offices of the rats (p=0.01). Conclusion: We conclude the aqueous extract of MO can have an important role in the reduction of the severity of WITHDRAWAL SYNDROME in rats.

Cites

A COMPARATIVE STUDY OF HYPOLIPIDEMIC ACTIVITIES OF THE EXTRACTS OF MELISSA OFFICINALIS AND BERBERIS VULGARIS IN RATS

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APA: Copy

MILADI GORJI, H., VAFAEI, ABAS ALI, TAHERIAN, ABAS ALI, & VAEZI, T.. (2008). THE EFFECTS OF AQUEOUS EXTRACTS OF MELISSA OFFICINAL IS ON WITHDRAWAL SYNDROME IN RATS. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 13(2 (SERIAL NUMBER 48)), 27-33. SID. https://sid.ir/paper/76306/en

Vancouver: Copy

MILADI GORJI H., VAFAEI ABAS ALI, TAHERIAN ABAS ALI, VAEZI T.. THE EFFECTS OF AQUEOUS EXTRACTS OF MELISSA OFFICINAL IS ON WITHDRAWAL SYNDROME IN RATS. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;13(2 (SERIAL NUMBER 48)):27-33. Available from: https://sid.ir/paper/76306/en

IEEE: Copy

H. MILADI GORJI, ABAS ALI VAFAEI, ABAS ALI TAHERIAN, and T. VAEZI, “THE EFFECTS OF AQUEOUS EXTRACTS OF MELISSA OFFICINAL IS ON WITHDRAWAL SYNDROME IN RATS,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 13, no. 2 (SERIAL NUMBER 48), pp. 27–33, 2008, [Online]. Available: https://sid.ir/paper/76306/en

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