Evaluation of Beclin 1 and Atg10 gene expression of the autophagy pathway in acute lymphoblastic leukemia patient

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Hasanpour Seyede Zahra; ALLAHBAKHSHIAN FARSANI MEHDI; HAJIFATHALI ABBAS; MOHAMMADI MOHAMMAD HOSSEIN

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Journal Paper

Paper Information

Journal: Scientific Journal of Kurdistan University of Medical Sciences Year:2019 | Volume:23 | Issue:6 (98) Page(s): 142-151

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Information Journal Paper

Title

Evaluation of Beclin 1 and Atg10 gene expression of the autophagy pathway in acute lymphoblastic leukemia patient

Author(s)

Hasanpour Seyede Zahra | ALLAHBAKHSHIAN FARSANI MEHDI | HAJIFATHALI ABBAS | MOHAMMADI MOHAMMAD HOSSEIN | Issue Writer Certificate

Keywords

Acute lymphoblastic leukemiaQ3

AutophagyQ1

Gene expressionQ2

Beclin1Q1

Atg 10Q1

RTPCRQ1

Abstract

Background and Aim: Acute lymphoblastic leukemia is the most common cancer in children and juveniles and is also seen in adults with lower frequency. Autophagy is a programmed catabolic process of the cell for destruction of damaged organs and proteins which is carried out by lysozymes. Disruption of Autophagy leads to abnormalities in cellular processes associated with cancer. Materials and Methods: In this study, we compared the expression of Beclin 1 and Atg 10 genes between 50 patients with B-ALL and 18 healthy subjects as our control group, by using RNA extraction and cDNA synthesis, and RT-PCR method. Data were analyzed by statistical tests. Results: The majority of B-ALL patients showed a significant reduction in the Beclin1 and Atg 10 genes compared to control group (P <0. 05) and the mean expression of the genes (2-Δ Ct ± SD) were 0. 10 ± 0. 49 and 1. 01 ± 0. 27 for ALL patients and control group and 0. 15± 0. 44 and 1. 07± 0. 85 for Atg10 and Beclin1 respectively. There was no significant correlation between expression levels of Beclin1and Atg10 in these patients (r =-0. 013, P =0. 926). Conclusion: Considering the reduced expression levels in the essential genes of Autophagy in ALL patients in our study and also other studies in this field, disruption of Autophagy may be involved in leukomogensis.

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APA: Copy

Hasanpour, Seyede Zahra, ALLAHBAKHSHIAN FARSANI, MEHDI, HAJIFATHALI, ABBAS, & MOHAMMADI, MOHAMMAD HOSSEIN. (2019). Evaluation of Beclin 1 and Atg10 gene expression of the autophagy pathway in acute lymphoblastic leukemia patient. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 23(6 (98) ), 142-151. SID. https://sid.ir/paper/76408/en

Vancouver: Copy

Hasanpour Seyede Zahra, ALLAHBAKHSHIAN FARSANI MEHDI, HAJIFATHALI ABBAS, MOHAMMADI MOHAMMAD HOSSEIN. Evaluation of Beclin 1 and Atg10 gene expression of the autophagy pathway in acute lymphoblastic leukemia patient. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;23(6 (98) ):142-151. Available from: https://sid.ir/paper/76408/en

IEEE: Copy

Seyede Zahra Hasanpour, MEHDI ALLAHBAKHSHIAN FARSANI, ABBAS HAJIFATHALI, and MOHAMMAD HOSSEIN MOHAMMADI, “Evaluation of Beclin 1 and Atg10 gene expression of the autophagy pathway in acute lymphoblastic leukemia patient,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 6 (98) , pp. 142–151, 2019, [Online]. Available: https://sid.ir/paper/76408/en

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