Effect of Myrtus Communis Hydro-Alcoholic Extract on Chronic Restraint Stress-Induced Spatial Memory Deficit in Adult Male Rats

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Jalalvand Fatemeh; Asle Rousta Masoumeh

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2018 | Volume:21 | Issue:3 (132) Page(s): 33-41

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Title

Effect of Myrtus Communis Hydro-Alcoholic Extract on Chronic Restraint Stress-Induced Spatial Memory Deficit in Adult Male Rats

Author(s)

Jalalvand Fatemeh | Asle Rousta Masoumeh | Issue Writer Certificate

Keywords

Myrtle (Myrtus communis)Q1

RatQ2

Restraint stressQ1

Spatial memoryQ2

Abstract

Background and Aim: Chronic Restraint stress impairs spatial learning and memory. Myrtle (Myrtus communis) has antioxidant, antidiabetic, hepatoprotective and neuroprotective properties. The aim of this study was to investigate the effect of myrtle hydroalcoholic extract on chronic Restraint stress-induced spatial learning and memory deficit in adult male Wistar Rats. Materials and Methods: In this experimental study, 80 adult male Wistar Rats were allocated to eight groups (10 in each) included control group (intact), myrtle0. 75, myrtle1. 5, myrtle3 groups (were gavaged with hydroalcoholic extract of myrtle at 0. 75, 1. 5 and 3 mg/ kg bw doses), stress group (restrained in restrainers for 6 hours per day for 21 consecutive days), stress-myrtle0. 75, stress-myrtle1. 5 and stressmyrtle3 groups (received myrtle extract at 0. 75, 1. 5 and 3 mg/ kg bw doses and exposed to chronic immobility stress). Spatial learning and memory were examined through the Morris water maze test. Findings: Chronic immobilization stress caused spatial learning and memory impairment. Consuming doses 1. 5 and 3 of Myrtle extract to stressed animals caused significant decrease in spent time and swam distance to reach the hidden platform (p<0. 05) and increased time lapsed in target quadrant comparing with stress group (p<0. 05). Conclusion: It has been concluded that myrtle extract can improve spatial learning and memory in Rats exposed to stress in a dose dependent manner.

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APA: Copy

Jalalvand, Fatemeh, & Asle Rousta, Masoumeh. (2018). Effect of Myrtus Communis Hydro-Alcoholic Extract on Chronic Restraint Stress-Induced Spatial Memory Deficit in Adult Male Rats. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 21(3 (132) ), 33-41. SID. https://sid.ir/paper/69885/en

Vancouver: Copy

Jalalvand Fatemeh, Asle Rousta Masoumeh. Effect of Myrtus Communis Hydro-Alcoholic Extract on Chronic Restraint Stress-Induced Spatial Memory Deficit in Adult Male Rats. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2018;21(3 (132) ):33-41. Available from: https://sid.ir/paper/69885/en

IEEE: Copy

Fatemeh Jalalvand, and Masoumeh Asle Rousta, “Effect of Myrtus Communis Hydro-Alcoholic Extract on Chronic Restraint Stress-Induced Spatial Memory Deficit in Adult Male Rats,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 21, no. 3 (132) , pp. 33–41, 2018, [Online]. Available: https://sid.ir/paper/69885/en

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