THE PROTECTIVE EFFECT OF AEROBIC EXERCISE ON BREAST CANCER BY TGFβ PROTEIN AND SMAD-3 AND MMP2 GENE IN FEMALE MICE

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MOGHADDAM V.; PEERI M.; AZARBAIJANI M.A.; MATIN HOMAEE H.

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Journal: SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES Year:2017 | Volume:22 | Issue:3 Page(s): 60-73

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Title

THE PROTECTIVE EFFECT OF AEROBIC EXERCISE ON BREAST CANCER BY TGFβ PROTEIN AND SMAD-3 AND MMP2 GENE IN FEMALE MICE

Author(s)

MOGHADDAM V. | PEERI M. | AZARBAIJANI M.A. | MATIN HOMAEE H. | Issue Writer Certificate

Keywords

BREAST CANCERQ2

AEROBIC CONTINUOUS TRAININGQ1

TGFβQ2

SMADQ1

MMP2Q1

Abstract

Background and Aim: The aim of this study was to investigate the protective effect of aerobic exercise on BREAST CANCER by TGF b protein and SMAD-3 and MMP2 gene in female mice.Material and method: Twenty-four female Balb/c mice were divided into control and exercise groups. Estrogen-receptor dependent BREAST CANCER cells (MC4-L2) were injected into the subcutaneous area of the right flank of the mice. the exercise group performed endurance exercise five sessions per week at an intensity of 60% to 65% VO2max for 10 weeks. Each session lasted 60 minutes.After appearance of the tumor, the length and width of the tumor were measured by a digital caliper once a week.Finally, the mice were sacrificed, tumor tissue was removed and immediately frozen and kept at -70oC. The level of TGF b protein was measured by western blot and expression of SMAD and MMP2 genes in the samples was measured by Real Time PCR.Data were analyzed by t-test. P<0.05 was considered significant.Results: The results showed that AEROBIC CONTINUOUS TRAINING significantly increased mean expression of SMAD-3 (p=0.033) and TGF-b protein mean concentration (P=0.000) in tumor tissue in the endurance group compared to those in the control group. Also, the results showed that aerobic training significantly decreased the mean expression of MMP-2 in tumor tissue in the endurance group compared to that in the control group (p=0.044).Conclusion: According to the results, It seems that continuous aerobic training may be an effective intervention to reduce BREAST CANCER progression.

Cites

A Comparison of the Effects of Two Methods of Aerobic and Combined Exercises on the Changes of Angiogenesis Factor TGF-β 1 and Cortisol Hormone in Healthy Elderly Men

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APA: Copy

MOGHADDAM, V., PEERI, M., AZARBAIJANI, M.A., & MATIN HOMAEE, H.. (2017). THE PROTECTIVE EFFECT OF AEROBIC EXERCISE ON BREAST CANCER BY TGFβ PROTEIN AND SMAD-3 AND MMP2 GENE IN FEMALE MICE. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 22(3 ), 60-73. SID. https://sid.ir/paper/76713/en

Vancouver: Copy

MOGHADDAM V., PEERI M., AZARBAIJANI M.A., MATIN HOMAEE H.. THE PROTECTIVE EFFECT OF AEROBIC EXERCISE ON BREAST CANCER BY TGFβ PROTEIN AND SMAD-3 AND MMP2 GENE IN FEMALE MICE. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;22(3 ):60-73. Available from: https://sid.ir/paper/76713/en

IEEE: Copy

V. MOGHADDAM, M. PEERI, M.A. AZARBAIJANI, and H. MATIN HOMAEE, “THE PROTECTIVE EFFECT OF AEROBIC EXERCISE ON BREAST CANCER BY TGFβ PROTEIN AND SMAD-3 AND MMP2 GENE IN FEMALE MICE,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 3 , pp. 60–73, 2017, [Online]. Available: https://sid.ir/paper/76713/en

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