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Information Journal Paper

Title

Short-Communication: Aqueous extract of Tamarindus indica fruit pulp exhibits antihyperglycaemic activity

Pages

  440-447

Abstract

 Objective: Tamarindus indica Linn. (T. indica) is a well-known plant used in traditional medicine. The plant is popular for its antidiabetic activity. However, effect so f its aqueous fruit pulp extract on carbohydrate hydrolyzing enzymes and its glucose uptake potential were not explored. Materials and Methods: The antidiabetic activity was assessed by in-vitro α-amylase and α-glucosidase inhibitory assays after preliminary phytochemical analysis. MTT assay was carried out to find cytotoxicity. Glucose uptake activity of the extract was carried out using L6 myotubes. Results: The results showed a strong α-amylase inhibitory activity for the fruit pulp extract of T. indica compared to standard acarbose; the IC50 of the fruit pulp extract of T. indica and acarbose was 34. 19 μ g/ml 34. 83μ M. The extract also showed moderate α-glucosidase inhibitory activity. IC50 of the fruit pulp extract of T. indica and acarbose were 56. 91μ g/ml and 45. 69μ M respectively. The cytotoxicity assay showed IC50 of >300μ g/ml and ≥ 1000μ M for the fruit pulp extract of T. indica and metformin. The extract showed 63. 99± 0. 08% glucose uptake in L6 myotubes whereas metformin and insulin at 10μ g/ml and 10μ M exhibited an uptake of 76. 99± 0. 3% and 84. 48± 0. 45% glucose, respectively. Conclusion: The study revealed that the fruit pulp extract of T. indica Linn does not show any cytotoxic effect and has very good α-amylase and good α-glucosidase inhibitory activities. The glucose uptake potential proves its postprandial hypoglycemic effect. Hence, it may be considered an antidiabetic agent for control of postprandial hyperglycemia.

Cites

References

Cite

APA: Copy

Nivesh Krishna, Rajesh, Anitha, Roy, & Ezhilarasan, Devaraj. (2020). Short-Communication: Aqueous extract of Tamarindus indica fruit pulp exhibits antihyperglycaemic activity. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 10(5), 440-447. SID. https://sid.ir/paper/769219/en

Vancouver: Copy

Nivesh Krishna Rajesh, Anitha Roy, Ezhilarasan Devaraj. Short-Communication: Aqueous extract of Tamarindus indica fruit pulp exhibits antihyperglycaemic activity. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2020;10(5):440-447. Available from: https://sid.ir/paper/769219/en

IEEE: Copy

Rajesh Nivesh Krishna, Roy Anitha, and Devaraj Ezhilarasan, “Short-Communication: Aqueous extract of Tamarindus indica fruit pulp exhibits antihyperglycaemic activity,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 10, no. 5, pp. 440–447, 2020, [Online]. Available: https://sid.ir/paper/769219/en

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