Cytotoxic effects of Melatonin on the Cell Line of Chronic Myeloid Leukemia K562 in Vitro

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AHANJAN M.; ABTAHI FROUSHANI S.M.

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Journal: Armaghane Danesh Year:2018 | Volume:23 | Issue:3 (128) Page(s): 303-316

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Title

Cytotoxic effects of Melatonin on the Cell Line of Chronic Myeloid Leukemia K562 in Vitro

Author(s)

AHANJAN M. | ABTAHI FROUSHANI S.M. | Issue Writer Certificate

Keywords

Cytotoxic effectsQ1

LeukemiaQ3

MelatoninQ2

K562Q2

Abstract

Background & Aim: Melatonin is produced from different sources in the body. In some of the previous studies, the effects of oncostatic Melatonin have been reported. The aim of this study was to evaluate the effects of Melatonin on K562 cells as a model for chronic myeloid Leukemia. Methods: In this experimental study, 6 × 104 cells of K562 cell line were treated with Melatonin for 24 hours with different concentrations of 0, 50, 75, 100, 150 and 200 μ M. The morphological changes of the treated cells were evaluated by inverse optical microscopy in comparison with the control sample. The effects of inhibition of Melatonin growth and fecundity were measured using MTT (dimethyl thiazole diphenyl tetrazolium bromide) and neutrally. The Wright-Gimsa staining was used to evaluate the distinction. Data were analyzed using Kruskal-Wallis statistical test. Results: There was with other concentrations in this cell line. The highest inhibitory effect of cellular growth was observed in high concentrations of Melatonin. Maximum cytotoxic effect of Melatonin on K562 cell line was observed at 200 μ m. However, at 50 μ m concentration, the effect of cytotoxicity of Melatonin was minimal (p <0. 05). Conclusion: Melatonin has the potential to inhibit proliferation of K562 cancer cells in vitro.

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APA: Copy

AHANJAN, M., & ABTAHI FROUSHANI, S.M.. (2018). Cytotoxic effects of Melatonin on the Cell Line of Chronic Myeloid Leukemia K562 in Vitro. ARMAGHAN DANESH, 23(3 (128) ), 303-316. SID. https://sid.ir/paper/77546/en

Vancouver: Copy

AHANJAN M., ABTAHI FROUSHANI S.M.. Cytotoxic effects of Melatonin on the Cell Line of Chronic Myeloid Leukemia K562 in Vitro. ARMAGHAN DANESH[Internet]. 2018;23(3 (128) ):303-316. Available from: https://sid.ir/paper/77546/en

IEEE: Copy

M. AHANJAN, and S.M. ABTAHI FROUSHANI, “Cytotoxic effects of Melatonin on the Cell Line of Chronic Myeloid Leukemia K562 in Vitro,” ARMAGHAN DANESH, vol. 23, no. 3 (128) , pp. 303–316, 2018, [Online]. Available: https://sid.ir/paper/77546/en

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