THE EFFECT OF HYDROALCOHLIC EXTRACT OF VALERIANA OFFICINALIS ON THE ASTROCYTES OF HIPPOCAMPUS IN RATS

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ROOZBEHI A.; DELAVIZ H.; HEIDARIAN A.; MOHAMADI J.

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Journal: Armaghane Danesh Year:2015 | Volume:20 | Issue:4 (99) Page(s): 298-308

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Title

THE EFFECT OF HYDROALCOHLIC EXTRACT OF VALERIANA OFFICINALIS ON THE ASTROCYTES OF HIPPOCAMPUS IN RATS

Author(s)

ROOZBEHI A. | DELAVIZ H. | HEIDARIAN A. | MOHAMADI J. | Issue Writer Certificate

Keywords

ASTROCYTESQ2

HIPPOCAMPUSQ2

VALERIANA OFFICINALISQ2

EXTRACTSQ2

Abstract

Background and aim: Valerian officinalis has various usages in the pharmaceutical industry and has therapeutic properties to improve some neurological disorders, insomnia and hysteria. The plant acts as sedatives for the nervous system and muscle cramps. The aim of this study was to evaluate the effect of the hydroalcoholic extract on the ASTROCYTES of HIPPOCAMPUS in rats.Methods: In the present experimental study, forty Sprague Dawley rats (200–230 g) were randomly divided into four groups. Experimental groups of one, two and three, received, 300, 400 and 600 mg/kg of VALERIANA OFFICINALIS extract daily for three weeks. But the control group received only one ml of distilled water by garage daily, for 21 days. At the end of the study, the rats were killed and their brain tissue samples were prepared.The size and number of ASTROCYTES in the HIPPOCAMPUS in the left hemisphere in CA1, CA2, and CA3 area were recorded in all groups.Data were analyzed by One-way ANOVA.Results: The numbers of ASTROCYTES of the CA1 and CA2 in the group which received 600 mg/kg of VALERIANA OFFICINALIS EXTRACTS were 16.79±6.48 and 9.11±3.91 respectively, which significantly increased compared with the control group (p<0.001). The mean of large diameter of ASTROCYTES in the CA1 region of the animals which received 300, 400 and 600 mg/kg of VALERIANA OFFICINALIS were 10.41±2.87, 7.85±2.36 and 5.5±2.06 respectively, which decreased significantly compared to the control group 13.1±4.01. The mean large diameter of the CA3 area in the groups which received 400 and 600 mg/kg of VALERIANA OFFICINALIS EXTRACTS were 8±2.38 and 7.13±4.12 which significantly reduced compared to the control group 14.53±8.60 (p<0.05).Conclusion: VALERIANA OFFICINALIS containing an effective compounds such as phenolic acids, esters, flavonoids, acids, esters, flavonoids, eccles, monoterpenes, and antioxidant property has potential to affect extracellular environment of the nervous system to proliferation of ASTROCYTES cells in the rat HIPPOCAMPUS.

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APA: Copy

ROOZBEHI, A., DELAVIZ, H., HEIDARIAN, A., & MOHAMADI, J.. (2015). THE EFFECT OF HYDROALCOHLIC EXTRACT OF VALERIANA OFFICINALIS ON THE ASTROCYTES OF HIPPOCAMPUS IN RATS. ARMAGHAN DANESH, 20(4 (99)), 298-308. SID. https://sid.ir/paper/77584/en

Vancouver: Copy

ROOZBEHI A., DELAVIZ H., HEIDARIAN A., MOHAMADI J.. THE EFFECT OF HYDROALCOHLIC EXTRACT OF VALERIANA OFFICINALIS ON THE ASTROCYTES OF HIPPOCAMPUS IN RATS. ARMAGHAN DANESH[Internet]. 2015;20(4 (99)):298-308. Available from: https://sid.ir/paper/77584/en

IEEE: Copy

A. ROOZBEHI, H. DELAVIZ, A. HEIDARIAN, and J. MOHAMADI, “THE EFFECT OF HYDROALCOHLIC EXTRACT OF VALERIANA OFFICINALIS ON THE ASTROCYTES OF HIPPOCAMPUS IN RATS,” ARMAGHAN DANESH, vol. 20, no. 4 (99), pp. 298–308, 2015, [Online]. Available: https://sid.ir/paper/77584/en

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