COMPARISON OF THE ANTIOXIDANT PROPERTIES OF VITAMINS E, C AND COPPER IN THE PREVENTION OF MOLYBDENUM TOXICITY IN RABBITS

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GERAYESH BORAZJANIAN H.; RASOOLI A.; SHAHRYARI A.; NAJAFZADEHVARZI H.; NOURI M.

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Journal: Armaghane Danesh Year:2013 | Volume:18 | Issue:3 (75) Page(s): 219-227

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Title

COMPARISON OF THE ANTIOXIDANT PROPERTIES OF VITAMINS E, C AND COPPER IN THE PREVENTION OF MOLYBDENUM TOXICITY IN RABBITS

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Keywords

ANTIOXIDANTQ2

MOLYBDENUMQ3

VITAMIN EQ2

VITAMIN CQ2

COPPERQ3

RABBITQ3

Abstract

Background & aim: Oxidative stress is defined as an imbalance between oxidants and reluctant in the individual or its cells. The aim of this study was to compare the effects of ANTIOXIDANT vitamins E and C in prevention of the toxicity of COPPER and MOLYBDENUM in RABBITs.Methods: In this experimental study, 25 adult RABBITs were randomly divided into 5 groups.The first group (control group) received no medication The second group received 80 mg/Kg/day sodium molybdate orally until symptoms of toxicity, the third group received 4 mg/kg of COPPER sulfate orally with sodium molybdate, Group IV 150 mg/kg of VITAMIN E with sodium molybdate orally, and group V 20 mg/kg orally received VITAMIN C with sodium molybdate. Using the total ANTIOXIDANT capacity parameters, malondialdehyde and ceruloplasmin levels in RABBIT’s serum parameters levels of oxidative stress and ANTIOXIDANT defense were obtained after a 35-day trial.The obtained data was analyzed using ANOVA and Turkey's test.Results: The results of the present study indicated that MOLYBDENUM induced alopecia and depigmentation and MOLYBDENUM as a stress factor increased levels of malondialdehyde. So that the amount of malondialdehyde from 1.285 in the control group to 1.849 m M/L MOLYBDENUM increased significantly. Although this indexes in the groups receiving VITAMIN E and C decreased significantly from 0.375 to 0.426 mM/L respectively. However, the total ANTIOXIDANT capacity in any of the groups compared with the control group showed no change.Conclusion: MOLYBDENUM toxicity is involved in the pathogenesis of oxidative stress and ANTIOXIDANT agents of vitamins E and C can reduce its toxic effects.

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APA: Copy

GERAYESH BORAZJANIAN, H., RASOOLI, A., SHAHRYARI, A., NAJAFZADEHVARZI, H., & NOURI, M.. (2013). COMPARISON OF THE ANTIOXIDANT PROPERTIES OF VITAMINS E, C AND COPPER IN THE PREVENTION OF MOLYBDENUM TOXICITY IN RABBITS. ARMAGHAN DANESH, 18(3 (75)), 219-227. SID. https://sid.ir/paper/77858/en

Vancouver: Copy

GERAYESH BORAZJANIAN H., RASOOLI A., SHAHRYARI A., NAJAFZADEHVARZI H., NOURI M.. COMPARISON OF THE ANTIOXIDANT PROPERTIES OF VITAMINS E, C AND COPPER IN THE PREVENTION OF MOLYBDENUM TOXICITY IN RABBITS. ARMAGHAN DANESH[Internet]. 2013;18(3 (75)):219-227. Available from: https://sid.ir/paper/77858/en

IEEE: Copy

H. GERAYESH BORAZJANIAN, A. RASOOLI, A. SHAHRYARI, H. NAJAFZADEHVARZI, and M. NOURI, “COMPARISON OF THE ANTIOXIDANT PROPERTIES OF VITAMINS E, C AND COPPER IN THE PREVENTION OF MOLYBDENUM TOXICITY IN RABBITS,” ARMAGHAN DANESH, vol. 18, no. 3 (75), pp. 219–227, 2013, [Online]. Available: https://sid.ir/paper/77858/en

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