ANTIMICROBIAL SUSCEPTIBILITY PATTERNS AND MOLECULAR EPIDEMIOLOGY OF PSEUDOMONAS AERUGINOSA ISOLATED FROM BURN PATIENTS

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ANVARINEJAD M.; JAPONI A.; RAFAATPOUR N.; ALIPOUR E.; ABBASI P.; SHAHIDI M.A.; MARDANEH J.

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Journal: Armaghane Danesh Year:2014 | Volume:19 | Issue:8 (91) Page(s): 694-706

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Title

ANTIMICROBIAL SUSCEPTIBILITY PATTERNS AND MOLECULAR EPIDEMIOLOGY OF PSEUDOMONAS AERUGINOSA ISOLATED FROM BURN PATIENTS

Author(s)

Keywords

BURN PATIENTSQ2

DRUG RESISTANCEQ2

NOSOCOMIAL INFECTIONSQ2

PSEUDOMONAS AERUGINOSAQ2

METALLO-Β-LACTAMASE (MBL) ENZYMEQ2

PULSED-FIELD GEL ELECTROPHORESIS (PFGE)Q2

Abstract

Background & aim: Because of emerging multi-drug resistance (MDR) PSEUDOMONAS AERUGINOSA strains, treatment of BURN PATIENTS infected by this bacterium is difficult. The aim of this study was to detect antimicrobial profile and molecular epidemiology of metallo-beta-lactamase (MBL) producer strains.Methods: In this cross-sectional investigation 270 PSEUDOMONAS AERUGINOSA isolates were collected from the BURN PATIENTS. Carbapenem sresistance strains were detected by phenotypic Etest method. Susceptibility profiles of metallo-b-lactamase (MβL) enzyme producing isolates of this bacterium to 11 antimicrobial drugs were determined by disc diffusion method according Clinical and Laboratory Standards Institute (CLSI) guidelines. The genetic correlations between isolates were determined by Pulsed-Field Gel Electrophoresis (PFGE) method.Results: Among 270 P. aeruginosa isolates, 60 (22.2%) strains showed resistant to meropenem (MEM) and imipenem (IMI) and were considered as metallo-b-lactamase positive. All metallo-β- lactamase positive isolates were resistant to five tested antimcrobial while their sensitivities to the three best effective antibiotics including ciprofloxacin, amikacin and ceftazidime were 1.7%, 6.7 % and 23.3%, respectively. Majority of the isolates (71.6%) showed more than 80% similarity based on the drawn dendrogram.Conclusion: Our results showed, the tested antimicrobials are not safe to prescribe for BURN PATIENTS. According PFGE pulsotypes, a limited number of P.aeruginosa types are common in the hospital burn units which infect the patients hospitalized in this ward.

Cites

FREQUENCY OF PLASMID-MEDIATED QUINOLONE RESISTANCE GENES AMONG CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA IN KERMAN, IRAN

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APA: Copy

ANVARINEJAD, M., JAPONI, A., RAFAATPOUR, N., ALIPOUR, E., ABBASI, P., SHAHIDI, M.A., & MARDANEH, J.. (2014). ANTIMICROBIAL SUSCEPTIBILITY PATTERNS AND MOLECULAR EPIDEMIOLOGY OF PSEUDOMONAS AERUGINOSA ISOLATED FROM BURN PATIENTS. ARMAGHAN DANESH, 19(8 (91)), 694-706. SID. https://sid.ir/paper/78040/en

Vancouver: Copy

ANVARINEJAD M., JAPONI A., RAFAATPOUR N., ALIPOUR E., ABBASI P., SHAHIDI M.A., MARDANEH J.. ANTIMICROBIAL SUSCEPTIBILITY PATTERNS AND MOLECULAR EPIDEMIOLOGY OF PSEUDOMONAS AERUGINOSA ISOLATED FROM BURN PATIENTS. ARMAGHAN DANESH[Internet]. 2014;19(8 (91)):694-706. Available from: https://sid.ir/paper/78040/en

IEEE: Copy

M. ANVARINEJAD, A. JAPONI, N. RAFAATPOUR, E. ALIPOUR, P. ABBASI, M.A. SHAHIDI, and J. MARDANEH, “ANTIMICROBIAL SUSCEPTIBILITY PATTERNS AND MOLECULAR EPIDEMIOLOGY OF PSEUDOMONAS AERUGINOSA ISOLATED FROM BURN PATIENTS,” ARMAGHAN DANESH, vol. 19, no. 8 (91), pp. 694–706, 2014, [Online]. Available: https://sid.ir/paper/78040/en

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