EFFECT OF C-PEPTIDE ON COGNITIVE DYSFUNCTION AND NEURONAL APOPTOSIS CAUSED BY BETA AMYLOID 1-42 IN DIABETIC RATS

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ABEDINZADEH M.; RASTGAR K.; ZARIFKAR A.

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Journal: Armaghane Danesh Year:2011 | Volume:16 | Issue:4 (64) Page(s): 311-320

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Title

EFFECT OF C-PEPTIDE ON COGNITIVE DYSFUNCTION AND NEURONAL APOPTOSIS CAUSED BY BETA AMYLOID 1-42 IN DIABETIC RATS

Author(s)

ABEDINZADEH M. | RASTGAR K. | ZARIFKAR A. | Issue Writer Certificate

Keywords

DIABETESQ2

C-PEPTIDEQ3

COGNITIVE IMPAIRMENTQ2

NEURONAL APOPTOSISQ2

Abstract

Background & Aim: Alzheimer disease is characterized by a progressive loss of memory. Its prevalence in diabetic patients is nearly twice in comparison of others. Recent findings suggest that C-PEPTIDE replacement in type 1 DIABETES exerts beneficial effects on diabetic rats. We examined the effects of C-PEPTIDE on cognitive dysfunction and NEURONAL APOPTOSIS caused by Ab 1-42 on working memory in Streptozotocin induced diabetic rats.Methods: In the present experimental study which was carried out in 2009 at Shiraz University of Medical Sciences, 50 male Sprague Dawley rats (230-300 gr) were divided into five groups: control, type 1 diabetic, diabetic groups receiving C-PEPTIDE, diabetic group receiving beta amyloid, diabetic group receiving beta amyloid and C-PEPTIDE. The NEURONAL APOPTOSIS were assessed with tunnel staining. DIABETES was induced with IV injection of Streptozotocin (60 mg/kg). Twenty six days after the onset of DIABETES, behavioral tests were conducted for three days. For data analysis, the Tukey and One way ANOVA tests were used.Results: In comparison to control group, in all diabetic groups working memory impairments was observed (P<0.05), but Ab 1-42 caused severe deficits in the working memory (P<0.001) and Cpeptide could significantly decrease the impairment (P<0.05). Only the diabetic beta amyloid group showed significant amount of tunnel positive neuron (P<0.05) and C-PEPTIDE replacement significantly decreased the amount of these cells (P<0.05).Conclusion: C-PEPTIDE could significantly decrease memory impairment and NEURONAL APOPTOSIS among diabetic rats.

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APA: Copy

ABEDINZADEH, M., RASTGAR, K., & ZARIFKAR, A.. (2011). EFFECT OF C-PEPTIDE ON COGNITIVE DYSFUNCTION AND NEURONAL APOPTOSIS CAUSED BY BETA AMYLOID 1-42 IN DIABETIC RATS. ARMAGHAN DANESH, 16(4 (64)), 311-320. SID. https://sid.ir/paper/78049/en

Vancouver: Copy

ABEDINZADEH M., RASTGAR K., ZARIFKAR A.. EFFECT OF C-PEPTIDE ON COGNITIVE DYSFUNCTION AND NEURONAL APOPTOSIS CAUSED BY BETA AMYLOID 1-42 IN DIABETIC RATS. ARMAGHAN DANESH[Internet]. 2011;16(4 (64)):311-320. Available from: https://sid.ir/paper/78049/en

IEEE: Copy

M. ABEDINZADEH, K. RASTGAR, and A. ZARIFKAR, “EFFECT OF C-PEPTIDE ON COGNITIVE DYSFUNCTION AND NEURONAL APOPTOSIS CAUSED BY BETA AMYLOID 1-42 IN DIABETIC RATS,” ARMAGHAN DANESH, vol. 16, no. 4 (64), pp. 311–320, 2011, [Online]. Available: https://sid.ir/paper/78049/en

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