COMPARISON OF NEW FORMULATION OF DICLOFENAC DIETHYLAMONIUM EMULGEL WITH STANDARD PREPARATION

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MOSTAFAVI S.A.; SHATALEBI M.A.; YAZDANIAN M.

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Journal: Armaghane Danesh Year:2006 | Volume:11 | Issue:2 (42) Page(s): 39-49

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Title

COMPARISON OF NEW FORMULATION OF DICLOFENAC DIETHYLAMONIUM EMULGEL WITH STANDARD PREPARATION

Author(s)

MOSTAFAVI S.A. | SHATALEBI M.A. | YAZDANIAN M. | Issue Writer Certificate

Keywords

SODIUM DICLOFENACQ3

EMULGELQ3

SKIN ABSORPTIONQ3

Abstract

Introduction & Objective: Oral route is a common route of vadministration for anti-inflammatory drugs including diclofenac. Due to some disadvantages of this route, the alternative routes of administrations are considered. The skin has been increasingly important in this regard, and many drugs have been formulated intradermal delivery systems. The purpose of this study was to prepare a topical diclofenac formulation EMULGEL with appropriate skin penetration and compare it with standard formulation.Materials & Methods: To prepare the formulation, we used the emulsion form. Several formulations containing different kinds and amounts of diclofenac salts, different emulsifying agents, and different HPMC concentrations were prepared. The skin penetration was evaluated by using Franz cell apparatus and the concentrations of diclofenac were determined in the receptor phase of Franz cell using spectrophotometer. The in vivo absorption of diclofenac was evaluated by determination of drug in urine. The concentration of drug was determined by HPLC. Results: In selected formulation, 85% of drug was released after 4 hours from formulation which was similar to drug released from standard formulation. The values of coefficient variation for HPLC method were utmost 15%. The range of variation in measurement was between 10 and 1000 ng/ml. Conclusion: The selected formulation had appropriate physicochemical properties. We were unable to measure drug concentrations in urine by the constructed HPLC, therefore it can be suggested that one should determine drug concentration in synovial fluid as the drug is concentrated in it.

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References

FORMULATION OF DICLOFENAC DIETHYLAMINE EMULGEL EVALUATION OF VARIOUS PENERATION ENHANCERS ON PERCUPANEOUS ABSORPTION OF THE DRUG FROM EMULGELS

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APA: Copy

MOSTAFAVI, S.A., SHATALEBI, M.A., & YAZDANIAN, M.. (2006). COMPARISON OF NEW FORMULATION OF DICLOFENAC DIETHYLAMONIUM EMULGEL WITH STANDARD PREPARATION. ARMAGHAN DANESH, 11(2 (42)), 39-49. SID. https://sid.ir/paper/78057/en

Vancouver: Copy

MOSTAFAVI S.A., SHATALEBI M.A., YAZDANIAN M.. COMPARISON OF NEW FORMULATION OF DICLOFENAC DIETHYLAMONIUM EMULGEL WITH STANDARD PREPARATION. ARMAGHAN DANESH[Internet]. 2006;11(2 (42)):39-49. Available from: https://sid.ir/paper/78057/en

IEEE: Copy

S.A. MOSTAFAVI, M.A. SHATALEBI, and M. YAZDANIAN, “COMPARISON OF NEW FORMULATION OF DICLOFENAC DIETHYLAMONIUM EMULGEL WITH STANDARD PREPARATION,” ARMAGHAN DANESH, vol. 11, no. 2 (42), pp. 39–49, 2006, [Online]. Available: https://sid.ir/paper/78057/en

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