Investigating the expressions of miRNA-125b and TP53 in endometriosis. Does it underlie cancer-like features of endometriosis? A case-control study

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Hajimaqsoudi Elnaz; Darbeheshti Farzaneh; KALANTAR SEYED MEHDI; JAVAHERI ATIYEH; Mirabutalebi Seyed Hamidreza; SHEIKHHA MOHAMMAD HASAN

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Journal: INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE Year:2020 | Volume:18 | Issue:10 Page(s): 825-836

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Title

Investigating the expressions of miRNA-125b and TP53 in endometriosis. Does it underlie cancer-like features of endometriosis? A case-control study

Author(s)

Keywords

Endometriosis

TP53

miR-125b

Ectopic endometrium

Eutopic endometrium

Abstract

Background: Endometriosis is generally considered as a benign condition; however, there is a possibility for it to become cancerous. miR-125b is upregulated in both endometriotic tissues and serum samples of women with endometriosis but its potential targets in endometriosis are still not fully understood. Objective: The role of miR-125b in the regulation of TP53 expression in endometriosis was tested with a bioinformatics approach. In addition, the expression of miR-125b and TP53 in both eutopic (Eu-p) and ectopic endometrium (Ec-p) in the endometrium tissues of women with endometriosis was compared to those in the normal endometrium tissues of controls (Normal). Materials and Methods: In this case-control study, the Eu-p and Ec-p samples were collected from 20 women who underwent laparoscopic surgery, and the normal endometrium tissues were collected from 20 controls with no evidence of endometriosis. For bioinformatics approach, a protein-protein interaction network was constructed based on co-expressed potential targets of miR-125b. Quantitative polymerase chain reaction technique was used for the measurement of miR125b and TP53 expression. Results: Our results showed that miR-125b was significantly overexpressed in Ec-p (p-value: 0. 021). In addition, there was a significant TP53 under expression in both the Ec-p and Eu-p samples compared with the Normal tissues (p-value: 0. 003). Conclusion: The negative correlation between miR-125b and TP53 as well as a noticeable decreased expression of TP53 in both Ec-p and Eu-p samples may be interpreted as the roles of miR-125b/TP53 axis in the pathogenesis of endometriosis. In addition, these findings and bioinformatic analyses imply a possible role of miR-125b in cancer-like features of endometriosis.

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APA: Copy

Hajimaqsoudi, Elnaz, Darbeheshti, Farzaneh, KALANTAR, SEYED MEHDI, JAVAHERI, ATIYEH, Mirabutalebi, Seyed Hamidreza, & SHEIKHHA, MOHAMMAD HASAN. (2020). Investigating the expressions of miRNA-125b and TP53 in endometriosis. Does it underlie cancer-like features of endometriosis? A case-control study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 18(10), 825-836. SID. https://sid.ir/paper/780588/en

Vancouver: Copy

Hajimaqsoudi Elnaz, Darbeheshti Farzaneh, KALANTAR SEYED MEHDI, JAVAHERI ATIYEH, Mirabutalebi Seyed Hamidreza, SHEIKHHA MOHAMMAD HASAN. Investigating the expressions of miRNA-125b and TP53 in endometriosis. Does it underlie cancer-like features of endometriosis? A case-control study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2020;18(10):825-836. Available from: https://sid.ir/paper/780588/en

IEEE: Copy

Elnaz Hajimaqsoudi, Farzaneh Darbeheshti, SEYED MEHDI KALANTAR, ATIYEH JAVAHERI, Seyed Hamidreza Mirabutalebi, and MOHAMMAD HASAN SHEIKHHA, “Investigating the expressions of miRNA-125b and TP53 in endometriosis. Does it underlie cancer-like features of endometriosis? A case-control study,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 18, no. 10, pp. 825–836, 2020, [Online]. Available: https://sid.ir/paper/780588/en

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