COMPARISON OF THERAPEUTIC EFFECTS OF BONE MARROW MESENCHYMAL STEM CELLS AND LIQUID CULTURE ENVIRONMENT (SECRETA) IN THE TREATMENT OF INDUCED KNEE ABRASION CREATED IN GUINEA PIGS

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SADRAIE M.R.; MEHRABANI D.; VAHDATI A.

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Journal: Armaghane Danesh Year:2015 | Volume:20 | Issue:8 (103) Page(s): 651-665

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Title

COMPARISON OF THERAPEUTIC EFFECTS OF BONE MARROW MESENCHYMAL STEM CELLS AND LIQUID CULTURE ENVIRONMENT (SECRETA) IN THE TREATMENT OF INDUCED KNEE ABRASION CREATED IN GUINEA PIGS

Author(s)

SADRAIE M.R. | MEHRABANI D. | VAHDATI A. | Issue Writer Certificate

Keywords

OSTEOARTHRITISQ2

BONE MARROW DERIVED MESENCHYMAL STEM CELLSQ2

SECRETAQ2

HEALINGQ3

BONE MARROWQ2

KNEE JOINTQ2

Abstract

Background & aim: OSTEOARTHRITIS is a common disease and painful arthritis of unknown etiology. The disease is associated with age and more in middle age and older. The aim of this study was to evaluate the effect of BONE MARROW DERIVED MESENCHYMAL STEM CELLS/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> BONE MARROW DERIVED MESENCHYMAL STEM CELLS (BM-MSCs) and SECRETA in HEALING of induced OA in guinea pig.Methods: BM-MSCs were extracted from guinea pig bone and cultured. OA was induced by cutting the anterior cruciate ligament in 15 guinea pigs. Then, 106 BM-MSCs at 3rd passage were administered to 5 animals, SECRETA was injected to 5 other and 5 were kept as the control group as untreated. After three months, the HEALING processes were evaluated by testing of histopathology and radiological parameters. The data were analyzed using Mann-Whitney U test and and P<0.05 was considered as significant difference.Results: The radiological assessment showed a significant reduction of OA in stem cells and SECRETA groups in comparison to the control group (P<0.05). Also OA histological feature in stem cells and SECRETA groups was better than control group. However, the matrix distribution of articular cartilage and collagen types 1 and 2 in SECRETA group were significantly better than other groups (P<0.05).Conclusion: The results showed that the use of BM-MSCs and their SECRETA in treatment of OA was associated with reduction of radiological and histological index of OA.

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APA: Copy

SADRAIE, M.R., MEHRABANI, D., & VAHDATI, A.. (2015). COMPARISON OF THERAPEUTIC EFFECTS OF BONE MARROW MESENCHYMAL STEM CELLS AND LIQUID CULTURE ENVIRONMENT (SECRETA) IN THE TREATMENT OF INDUCED KNEE ABRASION CREATED IN GUINEA PIGS. ARMAGHAN DANESH, 20(8 (103)), 651-665. SID. https://sid.ir/paper/78174/en

Vancouver: Copy

SADRAIE M.R., MEHRABANI D., VAHDATI A.. COMPARISON OF THERAPEUTIC EFFECTS OF BONE MARROW MESENCHYMAL STEM CELLS AND LIQUID CULTURE ENVIRONMENT (SECRETA) IN THE TREATMENT OF INDUCED KNEE ABRASION CREATED IN GUINEA PIGS. ARMAGHAN DANESH[Internet]. 2015;20(8 (103)):651-665. Available from: https://sid.ir/paper/78174/en

IEEE: Copy

M.R. SADRAIE, D. MEHRABANI, and A. VAHDATI, “COMPARISON OF THERAPEUTIC EFFECTS OF BONE MARROW MESENCHYMAL STEM CELLS AND LIQUID CULTURE ENVIRONMENT (SECRETA) IN THE TREATMENT OF INDUCED KNEE ABRASION CREATED IN GUINEA PIGS,” ARMAGHAN DANESH, vol. 20, no. 8 (103), pp. 651–665, 2015, [Online]. Available: https://sid.ir/paper/78174/en

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