THE EFFECT OF INTRAVENOUS AMINOPHYLLINE ON STONE FREE STATUS AFTER TRANSURETERAL LITHOTRIPSY (TUL): A RANDOMIZED DOUBLE BLIND CLINICAL TRIAL STUDY

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BARZEGARNEZHAD A.; EMADI S.A.; FIROUZIAN A.; SHARIFIAN R.; DANESHIAN M.; MONTAZAMI M.

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Journal: Armaghane Danesh Year:2015 | Volume:20 | Issue:7 (102) Page(s): 549-557

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Title

THE EFFECT OF INTRAVENOUS AMINOPHYLLINE ON STONE FREE STATUS AFTER TRANSURETERAL LITHOTRIPSY (TUL): A RANDOMIZED DOUBLE BLIND CLINICAL TRIAL STUDY

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Keywords

URETER STONEQ3

AMINOPHYLLINEQ2

LITHOTRIPSYQ2

Abstract

Background & aim: Among the different and new methods for treating urolithisis, ureteroscopy is the most popular modality for distal ureteral stones. The aim of this study is to evaluate the effect of intravenous AMINOPHYLLINE on the ureteral muscle spasm caused by acute phase of renal colic and finally its effect on the success rate of the transurethral ltihotripsy (TUL).Methods: In a double blind clinical trial, 88 patients with ureteral stones were randomized in 2 groups: AMINOPHYLLINE (group A) and normal saline (group B). One hour before operation during a period of 30 minutes, 250 mg AMINOPHYLLINE in 100 ml normal saline was infused in group A intravenously and 100 ml normal saline in group B at the same speed. The duration of operation, the success rate of TUL, and the need for accessory procedures such as ureteral stenting and Shock Wave LITHOTRIPSY (SWL) were recorded. The complications and success rates of operations were evaluated 2 weeks and again 3 months after operations. Analysis of the results was done by SPSS software version 18 and T-test.Results: The durations of operation for TUL in group A and B were 5.12±1.77 and 6.59±3.47 minutes, consecutively, that is statistically significant (p<0.05). The TUL success rate in group A and B were in 42 patients (97.6%) and 37 patients (84%), consecutively, that is statistically insignificant. There was also no statistical significant difference between necessity of accessory procedures such as DJ insertion and SWL, Vital signs including blood pressure and heart rate, before receiving medication and after anesthesia were identical in both groups.Conclusion: This study shows that although the duration of operation was statistically shorter in group A, there were not statistically significant differences in success rates and complications of TUL in both groups, but generally we can suggest that AMINOPHYLLINE may facilitate ureteroscopy. More studies with more sample sizes may be needed for documenting the effect of AMINOPHYLLINE on TUL.

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APA: Copy

BARZEGARNEZHAD, A., EMADI, S.A., FIROUZIAN, A., SHARIFIAN, R., DANESHIAN, M., & MONTAZAMI, M.. (2015). THE EFFECT OF INTRAVENOUS AMINOPHYLLINE ON STONE FREE STATUS AFTER TRANSURETERAL LITHOTRIPSY (TUL): A RANDOMIZED DOUBLE BLIND CLINICAL TRIAL STUDY. ARMAGHAN DANESH, 20(7 (102)), 549-557. SID. https://sid.ir/paper/78186/en

Vancouver: Copy

BARZEGARNEZHAD A., EMADI S.A., FIROUZIAN A., SHARIFIAN R., DANESHIAN M., MONTAZAMI M.. THE EFFECT OF INTRAVENOUS AMINOPHYLLINE ON STONE FREE STATUS AFTER TRANSURETERAL LITHOTRIPSY (TUL): A RANDOMIZED DOUBLE BLIND CLINICAL TRIAL STUDY. ARMAGHAN DANESH[Internet]. 2015;20(7 (102)):549-557. Available from: https://sid.ir/paper/78186/en

IEEE: Copy

A. BARZEGARNEZHAD, S.A. EMADI, A. FIROUZIAN, R. SHARIFIAN, M. DANESHIAN, and M. MONTAZAMI, “THE EFFECT OF INTRAVENOUS AMINOPHYLLINE ON STONE FREE STATUS AFTER TRANSURETERAL LITHOTRIPSY (TUL): A RANDOMIZED DOUBLE BLIND CLINICAL TRIAL STUDY,” ARMAGHAN DANESH, vol. 20, no. 7 (102), pp. 549–557, 2015, [Online]. Available: https://sid.ir/paper/78186/en

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