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Title

Does Bromelain-Cisplatin Combination Afford In-Vitro Synergistic Anticancer Effects on Human Prostatic Carcinoma Cell Line, PC3?

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  0-0

Abstract

 Background: Bromelain enhances anticancer impacts to chemotherapeutic agents. The question as to whether Bromelain does promote in-vitro cytotoxic and proapoptotic effects of Cisplatin on human prostatic carcinoma PC3 cell line was investigated. Materials and Methods: PC3 (human prostatic carcinoma) cells were treated either single or in combination with Bromelain and/or Cisplatin. MTT, clonogenic assay, flow cytometry and real-time quantitative polymerase chain reaction were used to investigate cell viability, colony formation, proapoptotic potential and p53 Gene expression, respectively. Results: Cisplatin (IC10 ) combined with Bromelain (IC40 ) significantly affected PC3 cell viability, inhibited colony formation, as well increased p53 proapoptotic gene expression compared to Cisplatin single treatment. Nevertheless, Bromelain-Cisplatin chemoherbal combination did not display any additive proapoptotic effect compared to single treatments. Conclusion: Bromelain-Cisplatin chemoherbal combination demonstrated synergistic in-vitro anticancer effect on human prostatic carcinoma cell line, PC3, that drastically reduced required Cisplatin dose.

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    APA: Copy

    Amini Chermahini, Fatemeh, Hossain Aazami, Mathias, MIRZAEI, SEYED ABBAS, HEIDARIAN, ESFANDIAR, & Lemoigne, Yves. (2020). Does Bromelain-Cisplatin Combination Afford In-Vitro Synergistic Anticancer Effects on Human Prostatic Carcinoma Cell Line, PC3?. GALEN MEDICAL JOURNAL, 9(1), 0-0. SID. https://sid.ir/paper/783795/en

    Vancouver: Copy

    Amini Chermahini Fatemeh, Hossain Aazami Mathias, MIRZAEI SEYED ABBAS, HEIDARIAN ESFANDIAR, Lemoigne Yves. Does Bromelain-Cisplatin Combination Afford In-Vitro Synergistic Anticancer Effects on Human Prostatic Carcinoma Cell Line, PC3?. GALEN MEDICAL JOURNAL[Internet]. 2020;9(1):0-0. Available from: https://sid.ir/paper/783795/en

    IEEE: Copy

    Fatemeh Amini Chermahini, Mathias Hossain Aazami, SEYED ABBAS MIRZAEI, ESFANDIAR HEIDARIAN, and Yves Lemoigne, “Does Bromelain-Cisplatin Combination Afford In-Vitro Synergistic Anticancer Effects on Human Prostatic Carcinoma Cell Line, PC3?,” GALEN MEDICAL JOURNAL, vol. 9, no. 1, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/783795/en

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