MIR-146A: A POSSIBLE TUMOR SUPPRESSORIN MULTIPLE MYELOMA

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KAZEMZADEH S.; FARSINEJAD A.; SABOUR TAKANLU J.; KAVIANI S.; ATASHI A.; SOLEIMANI M.; ABROUN S.

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Journal: The Scientific Journal of Iranian Blood Transfusion Year:2016 | Volume:13 | Issue:3 Page(s): 224-232

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Title

MIR-146A: A POSSIBLE TUMOR SUPPRESSORIN MULTIPLE MYELOMA

Author(s)

Keywords

MULTIPLE MYELOMAQ2

MICRORNASQ2

MIR-146AQ2

HUMANQ2

Abstract

Background and Objectives: MICRORNAS play a crucial role in controlling the innate and adaptive immune responses, inflammation, cell growth, and apoptosis by regulating gene expression at post-transcriptional level. In addition, many MICRORNAS act as oncogenes, tumor suppressors, and the mediators of cancer stem cells.MiR-146a is one of the important MICRORNAS in inflammatory diseases and tumors which has a dual effect on cancers and acts as a tumor promoter or a tumor suppressor. The present study aimed to evaluate the expression of MIR-146A in MULTIPLE MYELOMA cell lines (L363, LP1, RPMI 8226 and KMM1) in comparison with normal leukocytes.Materials and Methods: In this experimental study, four myeloma cell lines and peripheral blood leukocytes isolated from healthy individuals were cultured under specific conditions. After RNA extraction, MIR-146A expression was measured by quantitative Real Time PCR.Results: The research results showed that the expression of MIR-146A in MULTIPLE MYELOMA cell lines was significantly decreased compared with normal leukocytes. Data analysis also revealed that the expression of MIR-146A was decreased in average of 0.32±0.2 folds in L363 cell line and for LP1, RPMI 8226, and KMM1 cell lines in average of 0.03±0.07, 0.0035±0.02, 0.0022±0.001 folds, respectively (p<0.01).Conclusions: The researchers' results suggest that MIR-146A can act as a tumor suppressor in leukocytes, and the decreased expression of this microRNA in myeloma cells is likely to be effective at the onset and progression of MULTIPLE MYELOMA.

Cites

IN SILICO STUDIES REVEALED A CRUCIAL ROLE FOR MIR-146A ON PROGRESSION OF HELICOBACTER PYLORI INDUCED GASTRIC CANCER (REVIEW ARTICLE)

References

FOXP3 CONTROLS AN MIR-146/NF-ΚB NEGATIVE FEEDBACK LOOP THAT INHIBITS APOPTOSIS IN BREAST CANCER CELLS

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APA: Copy

KAZEMZADEH, S., FARSINEJAD, A., SABOUR TAKANLU, J., KAVIANI, S., ATASHI, A., SOLEIMANI, M., & ABROUN, S.. (2016). MIR-146A: A POSSIBLE TUMOR SUPPRESSORIN MULTIPLE MYELOMA. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 13(3), 224-232. SID. https://sid.ir/paper/78427/en

Vancouver: Copy

KAZEMZADEH S., FARSINEJAD A., SABOUR TAKANLU J., KAVIANI S., ATASHI A., SOLEIMANI M., ABROUN S.. MIR-146A: A POSSIBLE TUMOR SUPPRESSORIN MULTIPLE MYELOMA. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2016;13(3):224-232. Available from: https://sid.ir/paper/78427/en

IEEE: Copy

S. KAZEMZADEH, A. FARSINEJAD, J. SABOUR TAKANLU, S. KAVIANI, A. ATASHI, M. SOLEIMANI, and S. ABROUN, “MIR-146A: A POSSIBLE TUMOR SUPPRESSORIN MULTIPLE MYELOMA,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 13, no. 3, pp. 224–232, 2016, [Online]. Available: https://sid.ir/paper/78427/en

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