ASSOCIATION BETWEEN PLATELET COLLAGEN RECEPTOR POLYMORPHISMS WITH THE RISK OF STROKE IN THE MIDDLE-AGED

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FARSINEZHAD A.R.; SARVAR AZIMZADEH B.; KAZEMZADEH SH.

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Journal: THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON) Year:2014 | Volume:11 | Issue:3 Page(s): 207-213

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Title

ASSOCIATION BETWEEN PLATELET COLLAGEN RECEPTOR POLYMORPHISMS WITH THE RISK OF STROKE IN THE MIDDLE-AGED

Author(s)

FARSINEZHAD A.R. | SARVAR AZIMZADEH B. | KAZEMZADEH SH. | Issue Writer Certificate

Keywords

MYOCARDIAL INFARCTIONQ2

GENETIC POLYMORPHISMSQ2

PLATELETSQ3

Abstract

Background and Objectives: Arterial thrombosis, with MI as the severe complication, represents the most frequent cause of death in the world. Although there is no doubt that genetic factors contribute significantly to the prothrombotic state, the data on polymorphisms in candidate genes are still inconclusive. We investigated if T13254C polymorphism in the platelet GPVI gene confers an increased risk of premature acute MYOCARDIAL INFARCTION (MI).Materials and Methods: We conducted a case-control study of 100 young males with premature acute MI and 100 inpatient controls of the similar age, without any known heart diseases. Genotyping was done using PCR-RFLP. The significance of differences between cases and controls with respect to the variables was tested using student’s t test and Chi square. Logical regression model was used to control confounding variables.Results: The allele frequencies of T13254C polymorphism did not differ between patients (30%) and controls (33%), and this polymorphism was not associated with premature acute MI (p<0.05). Logistic regression analysis also indicated no association between these polymorphisms and premature MI.Conclusions: Compatible with our study, the T13254C polymorphism of platelet collagen receptor did not play a significant role in the development of premature MI.

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APA: Copy

FARSINEZHAD, A.R., SARVAR AZIMZADEH, B., & KAZEMZADEH, SH.. (2014). ASSOCIATION BETWEEN PLATELET COLLAGEN RECEPTOR POLYMORPHISMS WITH THE RISK OF STROKE IN THE MIDDLE-AGED. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 11(3), 207-213. SID. https://sid.ir/paper/78690/en

Vancouver: Copy

FARSINEZHAD A.R., SARVAR AZIMZADEH B., KAZEMZADEH SH.. ASSOCIATION BETWEEN PLATELET COLLAGEN RECEPTOR POLYMORPHISMS WITH THE RISK OF STROKE IN THE MIDDLE-AGED. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2014;11(3):207-213. Available from: https://sid.ir/paper/78690/en

IEEE: Copy

A.R. FARSINEZHAD, B. SARVAR AZIMZADEH, and SH. KAZEMZADEH, “ASSOCIATION BETWEEN PLATELET COLLAGEN RECEPTOR POLYMORPHISMS WITH THE RISK OF STROKE IN THE MIDDLE-AGED,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 11, no. 3, pp. 207–213, 2014, [Online]. Available: https://sid.ir/paper/78690/en

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