THE ROLE OF WNT/β-CATENIN SIGNALING PATHWAY IN BLOOD LEUKEMIAS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GHARI M.; FATHI E.; FARAHZADI R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON) Year:2018 | Volume:15 | Issue:2 Page(s): 149-164

Download Full-Text

Persian Verion

View:

3,663

Download:

Cites:

Information Journal Paper

Title

THE ROLE OF WNT/β-CATENIN SIGNALING PATHWAY IN BLOOD LEUKEMIAS

Author(s)

GHARI M. | FATHI E. | FARAHZADI R. | Issue Writer Certificate

Keywords

WNT SIGNALING PATHWAYQ1

LEUKEMIAQ1

CHRONIC MYELOIDQ1

ACUTE MYELOID LEUKEMIAQ1

ACUTE LYMPHOID LEUKEMIAQ1

CHRONIC LYMPHOCYTIC LEUKEMIAQ1

Abstract

Background and Objectives: Wnt/b-catenin signaling pathway is one of the key cascades regulating development and stability of immune and blood cells, but its precise role is still controversial and is the subject of many studies. With activation of the canonical Wnt/ b -catenin signaling pathway, b -catenin protein is imported into the nucleus and activates transcription of target genes including cyclin D1 and c-myc. The canonical Wnt ⁄ b -catenin signaling pathway is aberrantly activated in cancers, and it has therefore been investigated as a potential therapeutic target for the treatment of cancer. In this article, the significance of the canonical WNT SIGNALING PATHWAY and its impact on blood LEUKEMIAs development will be described, and how the change in the WNT SIGNALING PATHWAY will cause any types of LEUKEMIA.Materials and Methods: The data of the present article were obtained through the review of many papers published on the effect of Wnt / b -catenin signaling pathway on various types of LEUKEMIA.Results: The review of various studies has shown that Wnt / b -catenin signaling pathway (canonical and non-canonical) is involved at a specific stage during pathogenesis of all types of hematologic malignancies.Conclusions: Since the Wnt/ b -catenin signaling pathway plays an important role in the natural hematopoiesis and cellular malignancy in hematopoiesis system, evidently the changes in Wnt/ b -catenin signaling pathway provide therapeutic intervention opportunities, especially because of the significant increased level of Wnt/ b -catenin signaling pathway in hematologic malignancies compared to other signaling pathways.

Cites

No record.

References

Cite

APA: Copy

GHARI, M., FATHI, E., & FARAHZADI, R.. (2018). THE ROLE OF WNT/β-CATENIN SIGNALING PATHWAY IN BLOOD LEUKEMIAS. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 15(2 ), 149-164. SID. https://sid.ir/paper/78758/en

Vancouver: Copy

GHARI M., FATHI E., FARAHZADI R.. THE ROLE OF WNT/β-CATENIN SIGNALING PATHWAY IN BLOOD LEUKEMIAS. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2018;15(2 ):149-164. Available from: https://sid.ir/paper/78758/en

IEEE: Copy

M. GHARI, E. FATHI, and R. FARAHZADI, “THE ROLE OF WNT/β-CATENIN SIGNALING PATHWAY IN BLOOD LEUKEMIAS,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 15, no. 2 , pp. 149–164, 2018, [Online]. Available: https://sid.ir/paper/78758/en

Related Journal Papers