EFFECT OF ALOE VERA GEL ON TGF-β GENE EXPRESSION IN INCISIONAL SKIN WOUND IN BALB/C MICE

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JAFARZADEH H.; ARABI M.; NAJAFI N.; AHADI A.M.

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Journal: Journal of Gorgan University of Medical Sciences Year:2014 | Volume:16 | Issue:3 (51) Page(s): 16-23

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Title

EFFECT OF ALOE VERA GEL ON TGF-β GENE EXPRESSION IN INCISIONAL SKIN WOUND IN BALB/C MICE

Author(s)

JAFARZADEH H. | ARABI M. | NAJAFI N. | AHADI A.M. | Issue Writer Certificate

Keywords

SKINQ3

INCISIONAL WOUNDQ2

ALOE VERAQ2

TGF-β GENEQ2

MALONYLDIALDEHYDEQ2

MOUSEQ2

Abstract

Background and Objective: ALOE VERA (Aloe barbadensis M.) as a medicinal herb is practiced in wound healing. This study was carried out to assess the effect of ALOE VERA gel (mucilage) on TGF-b gene expression in incisional SKIN wound in BALB/c mice.Method: In this experimental study, 36 BALB/c male mice with weight range 22±2 gr were allocated equally into negative control (no wound), sham-operated (wound treated with physiological serum) and teratment (wound treated with ALOE VERA gel). Two equal full-thickness SKIN wounds of 10±2mm were made on either side of the vertebral column in the sacral region. The animals in the teratment group were received daily, 2 gram of ALOE VERA gel (without any bandage) as a thin layer for a period of 16 days. On 8th and 16th post wounding day, TGF-b gene expression in INCISIONAL WOUNDs and MALONYLDIALDEHYDE (as end-product of lipid peroxidation) in serum samples was measured using RT-PCR and spectrophotometry methods, respectively.Results: TGF-b gene expression in incisional SKIN wound increased in ALOE VERA gel treated group in compared to negative control and sham-operated groups (P<0.05). MALONYLDIALDEHYDE concentration was significantly reduced in ALOE VERA treated group in comparision with negative control and sham-operated groups.Conclusion: ALOE VERA gel can induce growth factor TGF-b gene expression and reducing the lipid peroxidation content can play an important role in incisional SKIN wound healing process.

Cites

Effect of Alcoholic Extract of Aloe Vera Gel (Aloe barabadensis) on Serum Urea, Uric Acid and Creatinine Levels and Tissue Structure of Kidney in Adult Mature Mice Treated with Ethidium Bromide

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APA: Copy

JAFARZADEH, H., ARABI, M., NAJAFI, N., & AHADI, A.M.. (2014). EFFECT OF ALOE VERA GEL ON TGF-β GENE EXPRESSION IN INCISIONAL SKIN WOUND IN BALB/C MICE. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 16(3 (51)), 16-23. SID. https://sid.ir/paper/78791/en

Vancouver: Copy

JAFARZADEH H., ARABI M., NAJAFI N., AHADI A.M.. EFFECT OF ALOE VERA GEL ON TGF-β GENE EXPRESSION IN INCISIONAL SKIN WOUND IN BALB/C MICE. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;16(3 (51)):16-23. Available from: https://sid.ir/paper/78791/en

IEEE: Copy

H. JAFARZADEH, M. ARABI, N. NAJAFI, and A.M. AHADI, “EFFECT OF ALOE VERA GEL ON TGF-β GENE EXPRESSION IN INCISIONAL SKIN WOUND IN BALB/C MICE,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 3 (51), pp. 16–23, 2014, [Online]. Available: https://sid.ir/paper/78791/en

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