EFFECT OF DIAZINON ON PITUITARY-GONADAL AXIS AND HISTOLOGICAL ALTERATION OF SEMINFEROUS TUBULES IN ADULT RAT TESTIS

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RAHIMI S.; ZAMIRI M.J.; SHARIATI M.; CHANGIZI ASHTIYANI S.; MOGHADAMNIA D.; RAHIMI A.

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Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2016 | Volume:18 | Issue:1 (57) Page(s): 23-29

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Title

EFFECT OF DIAZINON ON PITUITARY-GONADAL AXIS AND HISTOLOGICAL ALTERATION OF SEMINFEROUS TUBULES IN ADULT RAT TESTIS

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Keywords

DIAZINONQ2

TESTIS TISSUEQ2

TESTOSTERONEQ2

RATQ2

Abstract

Background and Objective: DIAZINON is an organophosphate insecticide., which inhibits the enzyme acetylcholinesterase. This study was done to evaluate the effect of DIAZINON on pituitary-gonadal axis and histological alteration of seminferous tubules in adult RAT testis.Methods: In this experimental study, 40 adult male Wistar RATs were randomly allocated into five groups including control, sham and experimental 1, 2 and 3. Animals in experimental group 1, 2 and 3 were received 50, 100 and 150 mg/kg/bw of DIAZINON for 28 days, orally, respectively. Animals in control group did not receive any substance. Animals in sham group were received an equivalent amount of normal saline. The animals were euthanized after 28 days and a blood sample was collected via heart puncture and testes were removed for histological studies.Results: DIAZINON significantly reduced serum TESTOSTERONE concentration, sertoli cell, leydig cell count, primary spermatocyte and spermatid (P<0.05). DIAZINON had no significant effect on the body and testis weight in the experimental groups compared to controls.Conclusion: DIAZINON reduces the concentration of TESTOSTERONE and cells in seminferous tubule in adult RAT.

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APA: Copy

RAHIMI, S., ZAMIRI, M.J., SHARIATI, M., CHANGIZI ASHTIYANI, S., MOGHADAMNIA, D., & RAHIMI, A.. (2016). EFFECT OF DIAZINON ON PITUITARY-GONADAL AXIS AND HISTOLOGICAL ALTERATION OF SEMINFEROUS TUBULES IN ADULT RAT TESTIS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 18(1 (57)), 23-29. SID. https://sid.ir/paper/78821/en

Vancouver: Copy

RAHIMI S., ZAMIRI M.J., SHARIATI M., CHANGIZI ASHTIYANI S., MOGHADAMNIA D., RAHIMI A.. EFFECT OF DIAZINON ON PITUITARY-GONADAL AXIS AND HISTOLOGICAL ALTERATION OF SEMINFEROUS TUBULES IN ADULT RAT TESTIS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;18(1 (57)):23-29. Available from: https://sid.ir/paper/78821/en

IEEE: Copy

S. RAHIMI, M.J. ZAMIRI, M. SHARIATI, S. CHANGIZI ASHTIYANI, D. MOGHADAMNIA, and A. RAHIMI, “EFFECT OF DIAZINON ON PITUITARY-GONADAL AXIS AND HISTOLOGICAL ALTERATION OF SEMINFEROUS TUBULES IN ADULT RAT TESTIS,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 18, no. 1 (57), pp. 23–29, 2016, [Online]. Available: https://sid.ir/paper/78821/en

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