EFFICACY OF ULTRAVIOLET RADIATION ON DRUG SUSCEPTIBILITY OF CANDIDA SPP. TO ITRACONAZOLE, FLUCONAZOLE AND AMPHOTERICIN B

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NOWROZI H.; KAZEMI A.; TESHFAM M.; TEMORIAN SH.; ADIMI P.; BASHASHATI M.

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Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2014 | Volume:15 | Issue:4 (48) Page(s): 53-58

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Title

EFFICACY OF ULTRAVIOLET RADIATION ON DRUG SUSCEPTIBILITY OF CANDIDA SPP. TO ITRACONAZOLE, FLUCONAZOLE AND AMPHOTERICIN B

Author(s)

Keywords

CANDIDAQ3

ULTRAVIOLET RADIATIONQ2

ITRACONAZOLEQ2

FLUCONAZOLEQ2

AMPHOTERICIN BQ3

DRUG RESISTANCEQ2

Abstract

Background and Objective: Ultraviolet (UV) radiation is a important disinfectant. Fungal infections with resistant isolates in patients culminate in recurrence of disease even with worse condition. This study was done to evaluate the efficacy of ULTRAVIOLET RADIATION on drug susceptibility of CANDIDA Spp. to ITRACONAZOLE, FLUCONAZOLE and AMPHOTERICIN B.Materials and Methods: This laboratory study was done on 12 CANDIDA spp. isolated from patients according to NCCLS M27- A method. Samples were suspended with sterile saline and optical density was read by spectrophotometer at the wavelength of 530 nm. Serial dilutions (0.0313-16 mg/ml) and (0.0313-128 mg/ml) were supplied for ITRACONAZOLE, amphotericin and FLUCONAZOLE, respectively. MICs were determined after 48h incubation at 35oC. Following UV radiation for 1, 2, 5, 10, 60, 90 and 120 seconds MICs were determined, subsequently.Results: The highest MIC pre UV radiation was (>128 mg/ml) for FLUCONAZOLE. After UV radiation, MICs were steadily decreased for all mentioned drugs while after 10 sec, MICs of ITRACONAZOLE and AMPHOTERICIN B were >0.0313 mg/ml. Secondary MICs significantly decreased with respect to MICs obtained in pre UV radiation (P<0.05).Conclusion: UV radiation reduces MICs of CANDIDA spp. to ITRACONAZOLE, FLUCONAZOLE, AMPHOTERICIN B.

Cites

COMPARING THE EFFECTS OF ALCOHOLIC EXTRACT OF GINSENG WITH ITRACONAZOLE AGAINSTCANDIDA ALBICANS AND CANDIDA KRUSEI

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APA: Copy

NOWROZI, H., KAZEMI, A., TESHFAM, M., TEMORIAN, SH., ADIMI, P., & BASHASHATI, M.. (2014). EFFICACY OF ULTRAVIOLET RADIATION ON DRUG SUSCEPTIBILITY OF CANDIDA SPP. TO ITRACONAZOLE, FLUCONAZOLE AND AMPHOTERICIN B. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 15(4 (48)), 53-58. SID. https://sid.ir/paper/78860/en

Vancouver: Copy

NOWROZI H., KAZEMI A., TESHFAM M., TEMORIAN SH., ADIMI P., BASHASHATI M.. EFFICACY OF ULTRAVIOLET RADIATION ON DRUG SUSCEPTIBILITY OF CANDIDA SPP. TO ITRACONAZOLE, FLUCONAZOLE AND AMPHOTERICIN B. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;15(4 (48)):53-58. Available from: https://sid.ir/paper/78860/en

IEEE: Copy

H. NOWROZI, A. KAZEMI, M. TESHFAM, SH. TEMORIAN, P. ADIMI, and M. BASHASHATI, “EFFICACY OF ULTRAVIOLET RADIATION ON DRUG SUSCEPTIBILITY OF CANDIDA SPP. TO ITRACONAZOLE, FLUCONAZOLE AND AMPHOTERICIN B,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 4 (48), pp. 53–58, 2014, [Online]. Available: https://sid.ir/paper/78860/en

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