PROTECTIVE EFFECT OF LEVOTHYROXINE WITH OXIDATIVE STRESS REDUCTION MECHANISM IN ISCHEMIC PRECONDITIONING MODEL IN RAT HEART

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Tajik Masoumeh; KHORI VAHID; MARJANI ABDOLJALAL; TAZIKI SHOHREH; ZEYGHAMI MOHAMMAD ALI; MANSOURIAN AZAD REZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Gorgan University of Medical Sciences Year:2018 | Volume:19 | Issue:4 (64) Page(s): 1-7

Download Full-Text

Persian Verion

View:

593

Download:

Cites:

Information Journal Paper

Title

PROTECTIVE EFFECT OF LEVOTHYROXINE WITH OXIDATIVE STRESS REDUCTION MECHANISM IN ISCHEMIC PRECONDITIONING MODEL IN RAT HEART

Author(s)

Keywords

HEARTQ2

ISCHEMIAQ2

LEVOTHYROXINEQ3

ISCHEMIC PRECONDITIONINGQ2

OXIDATIVE STRESSQ2

Abstract

Background and Objective: A brief and short duration episode of ISCHEMIA is recorded in ISCHEMIC PRECONDITIONING (IPC). This latter condition provides a status in which large region of HEART is protected when prolonged ISCHEMIA occurred. LEVOTHYROXINE play a protective role in IPC induction, and simultaneously with stress oxidative. This study was conducted to determine the protective effect of LEVOTHYROXINE with OXIDATIVE STRESS reduction mechanism in ISCHEMIC PRECONDITIONING model in rat HEART.Methods: This experimental study was performed on 30 male Wistar rats in three groups of 10, as follows. In the reperfusion ischaemia group (IR), the HEART of the animal was placed in a Langendorff apparatus. In the ISCHEMIC PRECONDITIONING group (IPC), prior to major ISCHEMIA, was exposed to 4 periods of 5-minute ISCHEMIA with reperfusion. In the intraperitoneally administered group, LEVOTHYROXINE at a dose of 25 microgram per 100 g of body weight, the HEART was exposed to reperfusion ISCHEMIA. The area of infarct and the level of malondialdehyde in the HEART tissue were measured.Results: The volume of Infarcted region in IR and IPC groups was 26.55 and 11.11 respectively.The same index for the LEVOTHYROXINE receiver was 12.56. Based on these findings it was demonstrated that LEVOTHYROXINE injection reduced the Infarcted region significantly similar with IPC (P<0.05). The MDA Levels in IR and IPC were 1328 and 777, respectively and in LEVOTHYROXINE group it was determined as 762. The size of Infarcted region in both IPC and treated with LEVOTHYROXINE groups significantly reduced in compared to IR group (P<0.05).Conclusion: Injection of LEVOTHYROXINE with ISCHEMIC PRECONDITIONING reduced the effect of reperfusion maladaptive ISCHEMIA in rat HEART.

Cites

No record.

References

No record.

Cite

APA: Copy

Tajik, Masoumeh, KHORI, VAHID, MARJANI, ABDOLJALAL, TAZIKI, SHOHREH, ZEYGHAMI, MOHAMMAD ALI, & MANSOURIAN, AZAD REZA. (2018). PROTECTIVE EFFECT OF LEVOTHYROXINE WITH OXIDATIVE STRESS REDUCTION MECHANISM IN ISCHEMIC PRECONDITIONING MODEL IN RAT HEART. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 19(4 (64) ), 1-7. SID. https://sid.ir/paper/79088/en

Vancouver: Copy

Tajik Masoumeh, KHORI VAHID, MARJANI ABDOLJALAL, TAZIKI SHOHREH, ZEYGHAMI MOHAMMAD ALI, MANSOURIAN AZAD REZA. PROTECTIVE EFFECT OF LEVOTHYROXINE WITH OXIDATIVE STRESS REDUCTION MECHANISM IN ISCHEMIC PRECONDITIONING MODEL IN RAT HEART. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;19(4 (64) ):1-7. Available from: https://sid.ir/paper/79088/en

IEEE: Copy

Masoumeh Tajik, VAHID KHORI, ABDOLJALAL MARJANI, SHOHREH TAZIKI, MOHAMMAD ALI ZEYGHAMI, and AZAD REZA MANSOURIAN, “PROTECTIVE EFFECT OF LEVOTHYROXINE WITH OXIDATIVE STRESS REDUCTION MECHANISM IN ISCHEMIC PRECONDITIONING MODEL IN RAT HEART,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 19, no. 4 (64) , pp. 1–7, 2018, [Online]. Available: https://sid.ir/paper/79088/en

Related Journal Papers