EFFECT OF HYDROALCOHOLIC EXTRACT OF FERULA PERSICA RESIN ON INDUCED RHEUMATOID ARTHRITIS BY FREUND'S COMPLETE ADJUVANT IN RAT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

RABANI NAHID; TEHRANIPOUR MARYAM; MAHDAVI SHAHRI NASER

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Gorgan University of Medical Sciences Year:2018 | Volume:20 | Issue:3 (67) Page(s): 24-30

Download Full-Text

Persian Verion

View:

577

Download:

Cites:

Information Journal Paper

Title

EFFECT OF HYDROALCOHOLIC EXTRACT OF FERULA PERSICA RESIN ON INDUCED RHEUMATOID ARTHRITIS BY FREUND'S COMPLETE ADJUVANT IN RAT

Author(s)

RABANI NAHID | TEHRANIPOUR MARYAM | MAHDAVI SHAHRI NASER | Issue Writer Certificate

Keywords

RHEUMATOID ARTHRITISQ2

FERULA PERSICA RESINQ1

INFLAMMATIONQ2

KNEE JOINTQ3

Abstract

Background and Objective: RHEUMATOID ARTHRITIS is an autoimmune-inflammatory disease with possible joint destruction and disability. Persica plant, seems contain anti-inflammatory capabilities. This study was done to determine the effect of hydroalcoholic extract of FERULA PERSICA RESIN on induced RHEUMATOID ARTHRITIS by Freund's complete adjuvant in rat.Methods: In this experimental study, 36 male Wistar rats (200-250 g) and 8 weeks old were randomly allocated in 6 groups including normal group, positive control, negative control, and groups treated with the hydroalcoholic extract of persica resin with 25, 50 and 75 mg/kg/bw doses. The resin of persica was extracted by Maceration method. On the first day, INFLAMMATION was induced with injection of 0.2 ml of Freund's complete adjuvant into the right KNEE JOINT of rats and from the fifteenth day hydroalcoholic extract was injected intraperitoneally and daily for 15 days. On the 30th day, blood samples were taken from hearts for rheumatoid factor measurement. Histological slides were prepared from KNEE JOINT.Results: The level of RF in the three treatment groups was significantly reduced compared to the negative control group (p<0.05). Destruction of cartilage were observed in treated group with dose of 25 mg/kg/bw in comparision with positive control group, treated group with 50 and 75 mg/kg/bw doses. Also in the negative control group, synovial hyperplasia, pannus and the destruction of cartilage were observed.Conclusion: It seems that hydroalcoholic extract of FERULA PERSICA RESIN can causes dose dependent reduction of INFLAMMATION and destruction of cartilage result from induced RHEUMATOID ARTHRITIS in the rats.

Cites

No record.

References

Cite

APA: Copy

RABANI, NAHID, TEHRANIPOUR, MARYAM, & MAHDAVI SHAHRI, NASER. (2018). EFFECT OF HYDROALCOHOLIC EXTRACT OF FERULA PERSICA RESIN ON INDUCED RHEUMATOID ARTHRITIS BY FREUND'S COMPLETE ADJUVANT IN RAT. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 20(3 (67) ), 24-30. SID. https://sid.ir/paper/79287/en

Vancouver: Copy

RABANI NAHID, TEHRANIPOUR MARYAM, MAHDAVI SHAHRI NASER. EFFECT OF HYDROALCOHOLIC EXTRACT OF FERULA PERSICA RESIN ON INDUCED RHEUMATOID ARTHRITIS BY FREUND'S COMPLETE ADJUVANT IN RAT. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;20(3 (67) ):24-30. Available from: https://sid.ir/paper/79287/en

IEEE: Copy

NAHID RABANI, MARYAM TEHRANIPOUR, and NASER MAHDAVI SHAHRI, “EFFECT OF HYDROALCOHOLIC EXTRACT OF FERULA PERSICA RESIN ON INDUCED RHEUMATOID ARTHRITIS BY FREUND'S COMPLETE ADJUVANT IN RAT,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 20, no. 3 (67) , pp. 24–30, 2018, [Online]. Available: https://sid.ir/paper/79287/en

Related Journal Papers