BRCA1 GENE EXPRESSION IN DMBA INDUCED BREAST CANCER IN RATS

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HAMTA A.; PARVINI P.

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Journal Paper

Paper Information

Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2013 | Volume:15 | Issue:3 (47) Page(s): 25-31

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Information Journal Paper

Title

BRCA1 GENE EXPRESSION IN DMBA INDUCED BREAST CANCER IN RATS

Author(s)

HAMTA A. | PARVINI P. | Issue Writer Certificate

Keywords

BREAST CANCERQ2

BRCA1 GENEQ2

G-BANDINGQ2

FISHQ2

RATQ2

Abstract

Background and Objective: BREAST CANCER is one of the most frequent malignancies among women. This study was done to determine the BRCA1 GENE expression in 7,12-Dimethylbenz(a)anthracene (DMBA) induced BREAST CANCER in RATs.Materials and Methods: In this experimental study, the BREAST CANCER was induced by DMBA in Sprague dawley RATs. After tumors arise, cell cultures were prepared and G-BANDING staining was performed on metaphase chromosomal smear. According to databases, genes in the affected area were collected and after comparing genome of the RATs and human in changed chromosomal segments, a gene list was prepared. FISH technique was performed on BRCA1 GENE to prove accuracy of chromosomal banding results.Results: Structural changes such as deletion occurred in chromosomes 10, which BRCA1 is located on. 24.7% of cells showed evidence of physical deletion in both copy of BRCA1 GENE and 23.8% of cells showed deletion in one copy.Conclusion: Induced DMBA BREAST CANCER cells showed deletion in BRCA1 copy numbers. This gene may be involved in animal breast tumor model.

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APA: Copy

HAMTA, A., & PARVINI, P.. (2013). BRCA1 GENE EXPRESSION IN DMBA INDUCED BREAST CANCER IN RATS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 15(3 (47)), 25-31. SID. https://sid.ir/paper/79331/en

Vancouver: Copy

HAMTA A., PARVINI P.. BRCA1 GENE EXPRESSION IN DMBA INDUCED BREAST CANCER IN RATS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2013;15(3 (47)):25-31. Available from: https://sid.ir/paper/79331/en

IEEE: Copy

A. HAMTA, and P. PARVINI, “BRCA1 GENE EXPRESSION IN DMBA INDUCED BREAST CANCER IN RATS,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 3 (47), pp. 25–31, 2013, [Online]. Available: https://sid.ir/paper/79331/en

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