ASSOCIATION OF VEGF GENE +405C/G POLYMORPHISM WITH THE RISK OF BREAST CANCER IN NORTHERN IRAN

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KARIMI ROUZBAHANI H.; MASHAYEKHI F.; SAEEDI SAEDI H.

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Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2017 | Volume:18 | Issue:4 (60) Page(s): 69-73

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Title

ASSOCIATION OF VEGF GENE +405C/G POLYMORPHISM WITH THE RISK OF BREAST CANCER IN NORTHERN IRAN

Author(s)

KARIMI ROUZBAHANI H. | MASHAYEKHI F. | SAEEDI SAEDI H. | Issue Writer Certificate

Keywords

BREAST CANCERQ1

POLYMORPHISM VEGFQ2

+405C/G GENEQ1

IRANQ1

Abstract

Background and Objective: BREAST CANCER is a cancer in women with high prevalancy worldwide. Vascular endothelial growth factor (VEGF) is one of the most important Pro-angiogenic factors. +405C/G is one of the common VEGF polymorphism which may have an impact on the level of gene expression and over loading of gene products. This study was done to evaluate the association between VEGF +405C/G gene polymorphism and BREAST CANCER risk in north of IRAN.Methods: This case-control study was carried out on 50 patients with BREAST CANCER and 50 normal aged-matched controls in north of IRAN. Genomic DNA was extracted from peripheral blood cells. To determine the genotype of+405 C/G VEGF gene polymorphism, PCR-RFLP method was used.Results: The prevalence of genotypic frequencies of GG, GC and CC in controls were 42%, 48% and 10%, respectively and in patients were 22%, 46% and 32%, respectively (P<0.05). The+405C allele was considered as a risk factor in BREAST CANCER (P<0.05).Conclusion: It seems+405 C/G VEGF gene polymorphism may be associated with the BREAST CANCER in northern IRAN.

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APA: Copy

KARIMI ROUZBAHANI, H., MASHAYEKHI, F., & SAEEDI SAEDI, H.. (2017). ASSOCIATION OF VEGF GENE +405C/G POLYMORPHISM WITH THE RISK OF BREAST CANCER IN NORTHERN IRAN. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 18(4 (60) ), 69-73. SID. https://sid.ir/paper/79527/en

Vancouver: Copy

KARIMI ROUZBAHANI H., MASHAYEKHI F., SAEEDI SAEDI H.. ASSOCIATION OF VEGF GENE +405C/G POLYMORPHISM WITH THE RISK OF BREAST CANCER IN NORTHERN IRAN. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;18(4 (60) ):69-73. Available from: https://sid.ir/paper/79527/en

IEEE: Copy

H. KARIMI ROUZBAHANI, F. MASHAYEKHI, and H. SAEEDI SAEDI, “ASSOCIATION OF VEGF GENE +405C/G POLYMORPHISM WITH THE RISK OF BREAST CANCER IN NORTHERN IRAN,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 18, no. 4 (60) , pp. 69–73, 2017, [Online]. Available: https://sid.ir/paper/79527/en

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