ASSOCIATION OF FAS GENE POLYMORPHISM (-1378G>A) WITH RISK OF BREAST CANCER IN NORTHWESTERN IRAN

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HOSSEINPOURFEIZI M.; DASTMALCHI N.; POULADI N.; SAFARALIZADEH R.; AZARFAM P.

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Journal: Journal of Ilam University of Medical Sciences Year:2017 | Volume:24 | Issue:6 Page(s): 117-126

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Title

ASSOCIATION OF FAS GENE POLYMORPHISM (-1378G>A) WITH RISK OF BREAST CANCER IN NORTHWESTERN IRAN

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Keywords

POLYMORPHISMQ1

FAS GENEQ1

BREAST CANCERQ2

Abstract

Introduction: Breast-cancer is the most common cancer among women. FAS GENE is crucial and important in the apoptotic pathway of cell death. Decreased expression of FAS GENE and consequently de-regulation of proapoptotic signaling have been seen in various tumors such as breast-tumors. Single-nucleotide POLYMORPHISMs in the promoter of FAS GENE such as G>A substitution at nucleotide position -1378 that is located within the Sp1 transcription-factor binding site, may influence FAS expression. This study investigated the association between FAS-1378G>A POLYMORPHISM and susceptibility to breast-cancer in northwestern Iran.Materials & methods: This study was conducted on 170 breast-cancer patients and 154 healthy controls. Different genotypes of FAS-1378G>A were determined using Tetra-ARMS-PCR and direct DNA-sequencing and compared.Findings: In the control-group, the genotype distribution of FAS POLYMORPHISM, showed 62.17%, 35.25%, 1.28% for GG, AG, AA genotypes, respectively. In the cancer-group, the distribution was 59.41%, 38.23% and 2.35% for GG, AG, AA genotypes, respectively. Distribution differences in the FAS-1378G>A POLYMORPHISM between the cases and controls were not statistically significant (p>0.05).Discussion & conclusions: The present investigation is the first study in regard to the association of FAS-1378G>A POLYMORPHISM with breast-cancer risk in northwestern population of Iran. The results of this study showed that there were no significant differences in the genotype/allele distribution between cases and controls. These findings suggest that FAS-1378G>A POLYMORPHISM may contribute to BREAST CANCER susceptibility in northwestern Iran. According to the results of this study, rs2234767 POLYMORPHISM can be as a marker for lymph-node involvement and age at diagnosis in the studied population.

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APA: Copy

HOSSEINPOURFEIZI, M., DASTMALCHI, N., POULADI, N., SAFARALIZADEH, R., & AZARFAM, P.. (2017). ASSOCIATION OF FAS GENE POLYMORPHISM (-1378G>A) WITH RISK OF BREAST CANCER IN NORTHWESTERN IRAN. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 24(6), 117-126. SID. https://sid.ir/paper/90340/en

Vancouver: Copy

HOSSEINPOURFEIZI M., DASTMALCHI N., POULADI N., SAFARALIZADEH R., AZARFAM P.. ASSOCIATION OF FAS GENE POLYMORPHISM (-1378G>A) WITH RISK OF BREAST CANCER IN NORTHWESTERN IRAN. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;24(6):117-126. Available from: https://sid.ir/paper/90340/en

IEEE: Copy

M. HOSSEINPOURFEIZI, N. DASTMALCHI, N. POULADI, R. SAFARALIZADEH, and P. AZARFAM, “ASSOCIATION OF FAS GENE POLYMORPHISM (-1378G>A) WITH RISK OF BREAST CANCER IN NORTHWESTERN IRAN,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 6, pp. 117–126, 2017, [Online]. Available: https://sid.ir/paper/90340/en

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