HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECT OF CHRONIC ORAL ADMINISTRATION OF AERIAL PART OF MARRUBIUM VULGARE IN DIABETIC RATS

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ROUGHANI M.; BALUCHNEJADMOJARAD TOURANDOKHT; ROUGHANI DEHKORDI F.

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Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2005 | Volume:7 | Issue:2 (16) Page(s): 1-5

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Title

HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECT OF CHRONIC ORAL ADMINISTRATION OF AERIAL PART OF MARRUBIUM VULGARE IN DIABETIC RATS

Author(s)

ROUGHANI M. | BALUCHNEJADMOJARAD TOURANDOKHT | ROUGHANI DEHKORDI F. | Issue Writer Certificate

Keywords

MARRUBIUM VULGAREQ3

HYPOGLYCEMIC CHOLESTEROLQ3

HYPOLIPIDEMICQ3

DIABETES MELLITUSQ3

STREPTOZOTOCINQ2

RATQ2

Abstract

Background & Objective: MARRUBIUM VULGARE has preventing and antioxident components. There aresome evidence of hypoglicemic and hypolepidemic of this medicinal herb. This study was done to determine the hypoglycemic and the HYPOLIPIDEMIC activities of MARRUBIUM VULGARE in diabetic RATs.Materials & Methods: In this experimental study, 40 male Wistar RATs were divided into control, treated control, diabetic, and treated diabetic groups. For induction of diabetes, STREPTOZOTOCIN (STZ; 60 mg/Kg; i.p.) was used at a single dose. The treatment groups received oral administration of plant-mixed pelleted food (6.25%) for two months. Serum glucose, triglyceride and cholesterol concentrations, were measured by spectrophotometer technique. Results: Serum glucose level in diabetic group increases 4 and 8 weeks after the experiment as compared to data one week before the study began (P<0.05). MARRUBIUM VULGARE treatment of diabetic RATs did not any significant effect. In addition, triglyceride level in diabetic group increased 8 weeks after the experiment in comparison with related data one week before the study (P<0.05) and there was a significant lower level of triglyceride in MARRUBIUM VULGARE- treated diabetic RATs (p<0.05). Furthermore, a similar significant reduction was obtained for treated-diabetic group as compared to diabetic group regarding serum cholesterol level (p<0.05). Conclusion: This study showed that oral administration of MARRUBIUM VULGARE in long-term could significantly reduce serum triglyceride and cholesterol levels without any effect on serum glucose in diabetic RATs.

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APA: Copy

ROUGHANI, M., BALUCHNEJADMOJARAD, TOURANDOKHT, & ROUGHANI DEHKORDI, F.. (2005). HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECT OF CHRONIC ORAL ADMINISTRATION OF AERIAL PART OF MARRUBIUM VULGARE IN DIABETIC RATS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 7(2 (16)), 1-5. SID. https://sid.ir/paper/79546/en

Vancouver: Copy

ROUGHANI M., BALUCHNEJADMOJARAD TOURANDOKHT, ROUGHANI DEHKORDI F.. HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECT OF CHRONIC ORAL ADMINISTRATION OF AERIAL PART OF MARRUBIUM VULGARE IN DIABETIC RATS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2005;7(2 (16)):1-5. Available from: https://sid.ir/paper/79546/en

IEEE: Copy

M. ROUGHANI, TOURANDOKHT BALUCHNEJADMOJARAD, and F. ROUGHANI DEHKORDI, “HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECT OF CHRONIC ORAL ADMINISTRATION OF AERIAL PART OF MARRUBIUM VULGARE IN DIABETIC RATS,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 7, no. 2 (16), pp. 1–5, 2005, [Online]. Available: https://sid.ir/paper/79546/en

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