STATUS OF ESTROGENE, PROGESTERONE RECEPTORS AND HER-2/NEU EXPRESSION IN INVASIVE BREAST CANCER

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NAGHSHVAR F.; TORABIZADEH ZH.; EMADIAN O.; ZARE A.; GHAHREMANI M.

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Journal: Journal of Gorgan University of Medical Sciences Year:2006 | Volume:8 | Issue:4 (20) Page(s): 64-67

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Title

STATUS OF ESTROGENE, PROGESTERONE RECEPTORS AND HER-2/NEU EXPRESSION IN INVASIVE BREAST CANCER

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Keywords

INVASIVE BREAST CANCERQ3

RECEPTORQ2

ESTROGENEQ2

PROGESTERONEQ2

HERQ3

2/NEUQ3

Abstract

Background & Objective: The breast cancer is the most common malignancy in women. The normal and malignant breast tissue is under the regulatory effects of esteroid hormones and growth factors including HER-2/neu. The purpose of this study is to determine the expression of estrogen RECEPTOR (ER) PROGESTERONE RECEPTOR (PR) and HER-2/neu among Iranian women with INVASIVE BREAST CANCER.Materials & Methods: The study is descriptive and cross-sectional that was performed on 50 samples of patients with INVASIVE BREAST CANCER in Imam-Khomeini Hospital-Sari (2005-06). After preparing the samples four tissue sections from each sample was obtained then H&E and IHC staining were performed.Results: In our study, the patients were between 28-88 yrs, (mean: 52/6). ER and PR and HER-2/neu were positive in 80%, 72% and 57.1% of cases, respectively. Concurrent positive ER and PR was 70%, meanwhile 62.9% of these patient were also positive for HER-2/neu. 20% of the cases showed negativity for both ER and PR and of these 83.4% were also negative for HER-2/neu.Conclusion: In our study ER expression by itself is equal to previous studies in textbooks but PR expression, HER-2/neu and concurrent expression of ER&PR are higher in our study. Interestingly HER-2/neu expression is near to what was previously proposed by Iranian Blood Transfusion Organization and Kerman University of Medical science. It seems that racial and geographic factors are contributed for these differences.

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APA: Copy

NAGHSHVAR, F., TORABIZADEH, ZH., EMADIAN, O., ZARE, A., & GHAHREMANI, M.. (2006). STATUS OF ESTROGENE, PROGESTERONE RECEPTORS AND HER-2/NEU EXPRESSION IN INVASIVE BREAST CANCER. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 8(4 (20)), 64-67. SID. https://sid.ir/paper/79586/en

Vancouver: Copy

NAGHSHVAR F., TORABIZADEH ZH., EMADIAN O., ZARE A., GHAHREMANI M.. STATUS OF ESTROGENE, PROGESTERONE RECEPTORS AND HER-2/NEU EXPRESSION IN INVASIVE BREAST CANCER. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;8(4 (20)):64-67. Available from: https://sid.ir/paper/79586/en

IEEE: Copy

F. NAGHSHVAR, ZH. TORABIZADEH, O. EMADIAN, A. ZARE, and M. GHAHREMANI, “STATUS OF ESTROGENE, PROGESTERONE RECEPTORS AND HER-2/NEU EXPRESSION IN INVASIVE BREAST CANCER,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 8, no. 4 (20), pp. 64–67, 2006, [Online]. Available: https://sid.ir/paper/79586/en

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