A STUDY OF CHEMISTRY AND ANTINOCICEPTIVE PROPERTIES OF MEDICINAL PLANT ALLIUM JESDIANUM LEAVES AND THE PROBABLE ROLE OF OPIOIDERGIC SYSTEM

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KHAKSARIAN M.; MESHKAT ALSADAT M.H.; FARAZIFARD R.; SAFARPOUR F.

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Journal: Yafteh Year:2008 | Volume:9 | Issue:4 (34) Page(s): 21-26

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Title

A STUDY OF CHEMISTRY AND ANTINOCICEPTIVE PROPERTIES OF MEDICINAL PLANT ALLIUM JESDIANUM LEAVES AND THE PROBABLE ROLE OF OPIOIDERGIC SYSTEM

Author(s)

KHAKSARIAN M. | MESHKAT ALSADAT M.H. | FARAZIFARD R. | SAFARPOUR F. | Issue Writer Certificate

Keywords

ALLIUM JESDIANUMQ3

ANTINOCICEPTIVEQ3

NALOXONEQ3

TAIL FLICKQ3

HOT PLATEQ3

RATQ3

Abstract

Background: In previous studies, ANTINOCICEPTIVE activity of ALLIUM JESDIANUM (AJ) has been evaluated using Formalin and TAIL FLICK tests. Therefore, the aim of this research is to study and analyze substances in extract and probable role of the opioidergic system.Materials and methods: AJ was collected from Lorestan province and was coded in Agriculture College of Lorestan University, and by the use of rotary device, it was extracted. The sample of the study was a group of 120 male Sprague-Dawely RATs weighing 180-220gr. and 50 other mice. AJ extract was administrated intra-peritoneally for the evaluation of its ANTINOCICEPTIVE effects. Pain models selected were TAIL FLICK and HOT PLATE. For the evaluation of the probable role of opioidergic NALOXONE an opioidergic antagonist was used in two pain models. Sensory motor performance was evaluated using Rotarod apparatus. Substances of extract using GC/Mass apparatus were analyzed.Results: Results of experiments showed that AJ administration increased TAIL FLICK and HOT PLATE latencies. NALOXONE pre-treatment inhibited ANTINOCICEPTIVE effects of AJ in both pain models. Sensory motor performance was not seen. IN extract analysis Morphin Cylerit, Ethyl cinamate, Isocoinoline, Neomantol and long chain alcohol were founded.Conclusion: In general, the experiments showed that AJ extract has ANTINOCICEPTIVE effects that is opposite to NALOXONE, and extract analysis proposed that Morphine Cylerit or Etyi Cinamate is suitable for this role.

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APA: Copy

KHAKSARIAN, M., MESHKAT ALSADAT, M.H., FARAZIFARD, R., & SAFARPOUR, F.. (2008). A STUDY OF CHEMISTRY AND ANTINOCICEPTIVE PROPERTIES OF MEDICINAL PLANT ALLIUM JESDIANUM LEAVES AND THE PROBABLE ROLE OF OPIOIDERGIC SYSTEM. YAFTEH, 9(4 (34)), 21-26. SID. https://sid.ir/paper/80032/en

Vancouver: Copy

KHAKSARIAN M., MESHKAT ALSADAT M.H., FARAZIFARD R., SAFARPOUR F.. A STUDY OF CHEMISTRY AND ANTINOCICEPTIVE PROPERTIES OF MEDICINAL PLANT ALLIUM JESDIANUM LEAVES AND THE PROBABLE ROLE OF OPIOIDERGIC SYSTEM. YAFTEH[Internet]. 2008;9(4 (34)):21-26. Available from: https://sid.ir/paper/80032/en

IEEE: Copy

M. KHAKSARIAN, M.H. MESHKAT ALSADAT, R. FARAZIFARD, and F. SAFARPOUR, “A STUDY OF CHEMISTRY AND ANTINOCICEPTIVE PROPERTIES OF MEDICINAL PLANT ALLIUM JESDIANUM LEAVES AND THE PROBABLE ROLE OF OPIOIDERGIC SYSTEM,” YAFTEH, vol. 9, no. 4 (34), pp. 21–26, 2008, [Online]. Available: https://sid.ir/paper/80032/en

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