Effects of omega 3 and vitamin E supplementation on Gene Expression of SIRT1, hTERT and serum level of hsCRP in CAD male patients: a randomized clinical trial study

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SABOORI S.; DJALALI M.; FALAHI E.; ABBASNEZHAD A.; ROOSTA S.; YOUSEFI RAD E.

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Journal: Yafteh Year:2019 | Volume:21 | Issue:2 (80) Page(s): 84-92

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Title

Effects of omega 3 and vitamin E supplementation on Gene Expression of SIRT1, hTERT and serum level of hsCRP in CAD male patients: a randomized clinical trial study

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Keywords

CADQ2

vitamin EQ2

omega 3Q2

hsCRPQ2

SIRT1Q1

hTERTQ1

Abstract

Background: Studies have shown that Sirtuins have critical roles in the regulation of inflammation and oxidative stress, while hTERT has a protective effect via increasing the length of telomers in cardiovascular disease. The aim of this study was to assess the effects of omega 3 and vitamin E supplementation on the gene expressions of SIRT1 and hTERT and serum hsCRP level in CAD patients. Materials and Methods: Participants in this Randomized Clinical Trial consisted of 60 nonsmoking male CAD patients, with age ranges 45-65 years, who were categorized into three groups, receiving: 4g/day of omega 3 and vitamin E placebo (OP); omega 3 (4g/day) and vitamin E 400IU/day (OE); and omega 3 and vitamin E placebos (PP) for two months. Results: Gene expression of SIRT1 increased significantly in the OE group (P = 0. 039), but gene expression of hTERT was not significantly different between the study groups. Supplementation with omega 3 and also co-administration of these fatty acids with vitamin E significantly decreased hsCRP level in OP and OE groups (P=0. 008 and P= 0. 050, respectively). Conclusion: Supplementation with omega 3 and vitamin E seems to include beneficial effects on CAD patients, possibly via increasing gene expression of SIRT1, and also by lowering inflammation through decreasing serum level of hsCRP in these patients.

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APA: Copy

SABOORI, S., DJALALI, M., FALAHI, E., ABBASNEZHAD, A., ROOSTA, S., & YOUSEFI RAD, E.. (2019). Effects of omega 3 and vitamin E supplementation on Gene Expression of SIRT1, hTERT and serum level of hsCRP in CAD male patients: a randomized clinical trial study. YAFTEH, 21(2 (80) ), 84-92. SID. https://sid.ir/paper/80089/en

Vancouver: Copy

SABOORI S., DJALALI M., FALAHI E., ABBASNEZHAD A., ROOSTA S., YOUSEFI RAD E.. Effects of omega 3 and vitamin E supplementation on Gene Expression of SIRT1, hTERT and serum level of hsCRP in CAD male patients: a randomized clinical trial study. YAFTEH[Internet]. 2019;21(2 (80) ):84-92. Available from: https://sid.ir/paper/80089/en

IEEE: Copy

S. SABOORI, M. DJALALI, E. FALAHI, A. ABBASNEZHAD, S. ROOSTA, and E. YOUSEFI RAD, “Effects of omega 3 and vitamin E supplementation on Gene Expression of SIRT1, hTERT and serum level of hsCRP in CAD male patients: a randomized clinical trial study,” YAFTEH, vol. 21, no. 2 (80) , pp. 84–92, 2019, [Online]. Available: https://sid.ir/paper/80089/en

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