INVESTIGATION OF KRAS AND NRAS EXPRESSION LEVELS IN LUNG CANCERPATIENTS COMPARED TO NORMAL PATIENTS

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RIKHTEGAR S.; HESAMPOUR A.

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Journal: Yafteh Year:2018 | Volume:20 | Issue:3 (77) Page(s): 18-27

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Information Journal Paper

Title

INVESTIGATION OF KRAS AND NRAS EXPRESSION LEVELS IN LUNG CANCERPATIENTS COMPARED TO NORMAL PATIENTS

Author(s)

RIKHTEGAR S. | HESAMPOUR A. | Issue Writer Certificate

Keywords

KRASQ1

NRASQ1

REAL TIME PCRQ1

MARKERQ1

LUNG CANCERQ2

Abstract

Background: LUNG CANCER is one of the most common cancers around the world, and a majorcause of death. The KRAS and NRAS genes could cause malfunction in signal transduction and cellcycle regulation. Materials and Methods: In this study, the expression level of KRAS and NRAS biomarkersamong 50 LUNG CANCER patients in comparison with 50 normal individuals was investigated. TotalRNA from blood samples was extracted and the cDNA synthesized. The specific primers fordetection of MARKERs were designed and the expression levels of KRAS and NRAS genes in thepresence GAPDH using the qRT-PCR method were quantitatively studied. Results: Quantitative comparison showed that KRAS and NRAS expression levels increasedsignificantly in LUNG CANCER patients compared to the control population. Results showed aquantitative increase of KRAS and NRAS genes with an increase of 2/05 and 3/43 fold respectively, for LUNG CANCER compared to normal samples. Conclusion: Based on current study results, we could quantitatively predict the expression level ofKRAS and NRAS genes in patients which could be used as a biomarker indicator during screeningof LUNG CANCER samples. This could also be used as a noninvasive method for the screening of thepopulation for early detection to inhibit cancer.

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APA: Copy

RIKHTEGAR, S., & HESAMPOUR, A.. (2018). INVESTIGATION OF KRAS AND NRAS EXPRESSION LEVELS IN LUNG CANCERPATIENTS COMPARED TO NORMAL PATIENTS. YAFTEH, 20(3 (77) ), 18-27. SID. https://sid.ir/paper/80151/en

Vancouver: Copy

RIKHTEGAR S., HESAMPOUR A.. INVESTIGATION OF KRAS AND NRAS EXPRESSION LEVELS IN LUNG CANCERPATIENTS COMPARED TO NORMAL PATIENTS. YAFTEH[Internet]. 2018;20(3 (77) ):18-27. Available from: https://sid.ir/paper/80151/en

IEEE: Copy

S. RIKHTEGAR, and A. HESAMPOUR, “INVESTIGATION OF KRAS AND NRAS EXPRESSION LEVELS IN LUNG CANCERPATIENTS COMPARED TO NORMAL PATIENTS,” YAFTEH, vol. 20, no. 3 (77) , pp. 18–27, 2018, [Online]. Available: https://sid.ir/paper/80151/en

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