THE ROLE OF CALMODULIN INHIBITION IN INTRATHECAL TRIFLUOPERAZINE-INDUCED ANALGESIA

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GOL BEYDI S.; GHAFGHAZI T.; HAJ HASHEMI V.A.; MORIUCHI H.

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Journal: Yafteh Year:2001 | Volume:3 | Issue:9 Page(s): 13-20

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Title

THE ROLE OF CALMODULIN INHIBITION IN INTRATHECAL TRIFLUOPERAZINE-INDUCED ANALGESIA

Author(s)

GOL BEYDI S. | GHAFGHAZI T. | HAJ HASHEMI V.A. | MORIUCHI H. | Issue Writer Certificate

Keywords

CALMODULIN INHIBITIONQ4

SUBARACHNOID SPACEQ4

TRIFLUOPERAZINEQ3

ANTINOCICEPTIONQ3

Abstract

Antipsychotic drugs are known to produce analgesic effects, but the mechanisms are not well established. In addition, some calmodulin inhibitors are reported to produce antinociceptive effects .Among antipsychotic drugs, TRIFLUOPERAZINE is one of the most potent calmodulin inhibitors. We examined which of the known properties of this drug, including anti-dopaminergic , anti-cholinergic ,anti -adrenergic ,anti -histaminic, and CALMODULIN INHIBITION are involved in its analgesic effect.The effects of various reagents by formalin test were evaluated 15 minutes after drug administration. AlI tested agents were injected through chronic subarachnoid catheter.Since antinociceptive measures with formalin test are based on motor function, we also used rotarod test to quantify motor side effects of the drugs. Intrathecal TRIFLUOPERAZINE showed antinociceptive effects in a biphasic fashion i.e., analgesia at relatively low doses (1, 10 mg/rat) and hyperalgesia at the higher dose (100 mg/rat). No analgesic effects were observed after intrathecal injection of sulpiride, atropine, phentolamine and brompheniramine. Meanwhile, intrathecal calmidazolium induced a dose dependent analgesia (10, 50, 2 50 mg/rat).Low doses of histamine (mg/rat), Physostigmine (mg/rat), bromocriptine (mg/rat) and norepinephrine (mg/rat)did not affect TRIFLUOPERAZINE -induced analgesia. Calcium attenuated antinociceptive effect of TRIFLUOPERAZINE-induced analgesic effect of calmidazolium . Finally, naloxone decreased TRIFLUOPERAZINE -induced ANTINOCICEPTION but did not have any effect on calmidazolium-induced analgesia.Regarding the above mentioned results we concluded that CALMODULIN INHIBITION may be involved in the analgesia produced by TRIFLUOPERAZINE. With increasing doses of TRIFLUOPERAZINE, algesic effect seems to overcome the analgesic effect. It is also suggested that the opioidergic system does not connect with - CALMODULIN INHIBITION" induced analgesia even though this system has partial role in TRIFLUOPERAZINE - induced analgesia.

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APA: Copy

GOL BEYDI, S., GHAFGHAZI, T., HAJ HASHEMI, V.A., & MORIUCHI, H.. (2001). THE ROLE OF CALMODULIN INHIBITION IN INTRATHECAL TRIFLUOPERAZINE-INDUCED ANALGESIA. YAFTEH, 3(9), 13-20. SID. https://sid.ir/paper/80238/en

Vancouver: Copy

GOL BEYDI S., GHAFGHAZI T., HAJ HASHEMI V.A., MORIUCHI H.. THE ROLE OF CALMODULIN INHIBITION IN INTRATHECAL TRIFLUOPERAZINE-INDUCED ANALGESIA. YAFTEH[Internet]. 2001;3(9):13-20. Available from: https://sid.ir/paper/80238/en

IEEE: Copy

S. GOL BEYDI, T. GHAFGHAZI, V.A. HAJ HASHEMI, and H. MORIUCHI, “THE ROLE OF CALMODULIN INHIBITION IN INTRATHECAL TRIFLUOPERAZINE-INDUCED ANALGESIA,” YAFTEH, vol. 3, no. 9, pp. 13–20, 2001, [Online]. Available: https://sid.ir/paper/80238/en

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