ANTIFUNGAL ACTIVITY OF ESSENTIAL OIL AND ALCOHOLIC EXTRACT OF CARUM COPTICUM AGAINST FLUCONAZOLE RESISTANT AND SUSCEPTIBLE CANDIDA ALBICANS ISOLATED

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SATARI MORTEZA; NATANZIAN GHAHFAROKHI M.; YADGARI M.H.; GOUDARZI GH.R.; SAHARKHIZ M.J.

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Journal: Pathobiology Research Year:2008 | Volume:11 | Issue:1-2 Page(s): 91-97

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Title

ANTIFUNGAL ACTIVITY OF ESSENTIAL OIL AND ALCOHOLIC EXTRACT OF CARUM COPTICUM AGAINST FLUCONAZOLE RESISTANT AND SUSCEPTIBLE CANDIDA ALBICANS ISOLATED

Author(s)

Keywords

CANDIDA ALBICANSQ3

FLUCONAZOLEQ3

CARUM COPTICUMQ3

ANTIFUNGAL EFFECTSQ2

Abstract

Objective: Ajowan is an annual herbaceous essential oil of Carum copticom. The main components of the oil are Tymol, b-pinene, g- terpinene and Sabinene. The fruit oil of CARUM COPTICUM has been reported to have several therapeutic effects including anti fungal, anti bacterial and anti viral, ... CANDIDA ALBICANS is an opportunistic fungus and transforms into pathogenic form in favorable conditions, causing fungal diseases.Materials and Methods: In this study, essential oil and alcoholic extract of CARUM COPTICUM were gained and Microdilution Broth method were used for detection of minimum inhibition concentration (MIC) and minimum fungicide concentration (MFC) of 11 clinical isolates of CANDIDA ALBICANS and Standard strain (PTCC50-27).Results: Results show that MIC for essential oil is 0.43mg/ml, 0.87mg/ml and for alcoholic extract is 3.51mg/ml, 7.03mg/ml, 1/75mg/ml. Thus, it seems that CARUM COPTICUM could inhibit CANDIDA ALBICANS growth by a similar mechanism which occurs by FLUCONAZOLE (FLZ). In general, the results obtained in this study indicate that CARUM COPTICUM has potential values for growth inhibition of CANDIDA ALBICANS in vitro.Conclusion: In recent years, systemic fungal infections due to Candida species have been received major consideration about inducing mortality in nosocomial patients because of increasing in immunocompromised disorders such as AIDS and hematological disorders as well as long term use of broad spectrum antibiotics and corticosteroids. The present study was done with the aim of evaluating ANTIFUNGAL EFFECTS of essential oil and alcoholic extract from CARUM COPTICUM against FLUCONAZOLE (FLZ) susceptible and FLUCONAZOLE resistance CANDIDA ALBICANS strains isolated from different types of Candidiasis. Standard drug susceptibility tests with broth dilution technique were used to measure the in vitro antifungal activity of essential oil and alcoholic extract from CARUM COPTICUM. According to our results, it seems that CARUM COPTICUM could inhibit CANDIDA ALBICANS growth by a similar mechanism which occurs by FLZ and could be used as a potential antifungal agent especially with FLZ.

Cites

ANTIFUNGAL EFFECTS OF THREE PLANT ESSENTIAL OILS AGAINST RHIZOPUS STOLONIFER, THE CAUSE OF SOFT ROT ON STRAWBERRY FRUIT

References

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APA: Copy

SATARI, MORTEZA, NATANZIAN GHAHFAROKHI, M., YADGARI, M.H., GOUDARZI, GH.R., & SAHARKHIZ, M.J.. (2008). ANTIFUNGAL ACTIVITY OF ESSENTIAL OIL AND ALCOHOLIC EXTRACT OF CARUM COPTICUM AGAINST FLUCONAZOLE RESISTANT AND SUSCEPTIBLE CANDIDA ALBICANS ISOLATED. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 11(1-2), 91-97. SID. https://sid.ir/paper/81133/en

Vancouver: Copy

SATARI MORTEZA, NATANZIAN GHAHFAROKHI M., YADGARI M.H., GOUDARZI GH.R., SAHARKHIZ M.J.. ANTIFUNGAL ACTIVITY OF ESSENTIAL OIL AND ALCOHOLIC EXTRACT OF CARUM COPTICUM AGAINST FLUCONAZOLE RESISTANT AND SUSCEPTIBLE CANDIDA ALBICANS ISOLATED. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2008;11(1-2):91-97. Available from: https://sid.ir/paper/81133/en

IEEE: Copy

MORTEZA SATARI, M. NATANZIAN GHAHFAROKHI, M.H. YADGARI, GH.R. GOUDARZI, and M.J. SAHARKHIZ, “ANTIFUNGAL ACTIVITY OF ESSENTIAL OIL AND ALCOHOLIC EXTRACT OF CARUM COPTICUM AGAINST FLUCONAZOLE RESISTANT AND SUSCEPTIBLE CANDIDA ALBICANS ISOLATED,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 11, no. 1-2, pp. 91–97, 2008, [Online]. Available: https://sid.ir/paper/81133/en

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