ROLE OF DOPAMINERGIC RECEPTORS ON THE PLASMA GLUCOSE LEVEL IN MICE

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ELIASI AFSANEH; MOUMENI HAMID REZA

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Journal: Pathobiology Research Year:2001 | Volume:4 | Issue:1 Page(s): 1-8

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Information Journal Paper

Title

ROLE OF DOPAMINERGIC RECEPTORS ON THE PLASMA GLUCOSE LEVEL IN MICE

Author(s)

ELIASI AFSANEH | MOUMENI HAMID REZA | Issue Writer Certificate

Keywords

PLASMA GLUCOSEQ4

DOPAMINERGIC SYSTEMQ4

APOMORPHINE LY171555Q4

Abstract

Dopamine (DA) is one of the predominant cathecolaminneurotransmitter in the mammalian brain playing its' role through the D1-and D2 - Like recptors. The dopamine-induced hyperglycemia has already been reported, but the type of receptors involved in this process is still controversial. In this study we investigated the role of D1 and D2-like receptors on the PLASMA GLUCOSE by specifc dopaminergic agonists and antagonists in the Albino mouse. Subcutaneous administration of apomorphine (0.25, 0.5, and 1mg/kg) induced a dose-dependent hyperglycemia. This response was decreased by the blockade of the D1 and D2 receptors by the SCH and sulpiride respectively. Activation of the D2-like receptors by high doses of the LY171555 produced a significant hyperglycemia which was reduced by the sulpiride. Stimulation of the D1- like receptors by the specific D1 agonist, SKF38393, caused an increase in the PLASMA GLUCOSE which was not affected by the SCH. At low doses, apomorphine and SKF induced hypoglycemia in the second and third hours after the injection.In conclusion, DOPAMINERGIC SYSTEM seems to have a dual stimulatory and inhibitory effect on the PLASMA GLUCOSE. The exact mechanisms of the stimulatory effect, mediated by the D2-like receptors, and the inhibitory effect of the DOPAMINERGIC SYSTEM needs more investigation.

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APA: Copy

ELIASI, AFSANEH, & MOUMENI, HAMID REZA. (2001). ROLE OF DOPAMINERGIC RECEPTORS ON THE PLASMA GLUCOSE LEVEL IN MICE. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 4(1), 1-8. SID. https://sid.ir/paper/81271/en

Vancouver: Copy

ELIASI AFSANEH, MOUMENI HAMID REZA. ROLE OF DOPAMINERGIC RECEPTORS ON THE PLASMA GLUCOSE LEVEL IN MICE. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2001;4(1):1-8. Available from: https://sid.ir/paper/81271/en

IEEE: Copy

AFSANEH ELIASI, and HAMID REZA MOUMENI, “ROLE OF DOPAMINERGIC RECEPTORS ON THE PLASMA GLUCOSE LEVEL IN MICE,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 4, no. 1, pp. 1–8, 2001, [Online]. Available: https://sid.ir/paper/81271/en

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