COMPARISON OF THE EFFECT OF BROMOCRIPTINE AND QUINPIROLE ON PLASMA GLUCOSE LEVEL IN MICE

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ELIASI A.; SAHRAIE H.

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Journal: Physiology and Pharmacology Year:2002 | Volume:5 | Issue:2 Page(s): 161-170

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Title

COMPARISON OF THE EFFECT OF BROMOCRIPTINE AND QUINPIROLE ON PLASMA GLUCOSE LEVEL IN MICE

Author(s)

ELIASI A. | SAHRAIE H. | Issue Writer Certificate

Keywords

DOPAMINERGIC SYSTEMQ4

PLASMA GLUCOSEQ4

QUINPIROLEQ4

BROMOCRIPTINEQ3

Abstract

Dopamine is the predominant catecholamine neurotransmitter in the mammalian brain. The dopamine-induced hyperglycemia has already been reported. We have shown previously that activation of D2 like receptors produced a significant hyperglycemia.In the present study the effect of two selective D2 agonists, BROMOCRIPTINE and QUINPIROLE on PLASMA GLUCOSE level was compared in male albino mice. Blood samples were obtained from retra-orbital sinus by the Stone procedure and blood glucose was measured by orto-toluidine method. BROMOCRIPTINE (0.125, 0.5, and 2 mg/Kg) and QUINPIROLE (0.25, 0.5, and 1 mg/Kg) caused marked hyperglycemia. The effect of BROMOCRIPTINE and QUINPIROLE was dose- and time-dependent, producing the maximum response 60 and 150 minutes after drawing the first blood samples. BROMOCRIPTINE-induced hyperglycemia was elevated by sulpiride 25 mg/Kg. while decreased by sulpiride (100 mg/Kg) and domperidone (30 mg/Kg). The blocking effect of sulpiride was developed from the beginning of experiments, while the effect of BROMOCRIPTINE was observed one hour after the injection. QUINPIROLE-induced hyperglycemia was prevented by domperidone but not by sulpiride.It can be concluded that central and peripheral metabolic pathways may be involved in BROMOCRIPTINE-induced hyperglycemia through D2 receptors, while quinpiroIe-induced hyperglycemia is produced through peripheral mechanisms by other dopamine receptors which are insensitive to sulpiride.

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APA: Copy

ELIASI, A., & SAHRAIE, H.. (2002). COMPARISON OF THE EFFECT OF BROMOCRIPTINE AND QUINPIROLE ON PLASMA GLUCOSE LEVEL IN MICE. PHYSIOLOGY AND PHARMACOLOGY, 5(2), 161-170. SID. https://sid.ir/paper/74983/en

Vancouver: Copy

ELIASI A., SAHRAIE H.. COMPARISON OF THE EFFECT OF BROMOCRIPTINE AND QUINPIROLE ON PLASMA GLUCOSE LEVEL IN MICE. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2002;5(2):161-170. Available from: https://sid.ir/paper/74983/en

IEEE: Copy

A. ELIASI, and H. SAHRAIE, “COMPARISON OF THE EFFECT OF BROMOCRIPTINE AND QUINPIROLE ON PLASMA GLUCOSE LEVEL IN MICE,” PHYSIOLOGY AND PHARMACOLOGY, vol. 5, no. 2, pp. 161–170, 2002, [Online]. Available: https://sid.ir/paper/74983/en

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