IDENTIFICATION AND DISCOVERY OF NOVEL MICRORNAS IN THE HUMAN GENOME

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DOKANEHIIFARD SADAT; MOHAMMAD SOLTANI BAHRAM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Pathobiology Research Year:2015 | Volume:18 | Issue:1 Page(s): 1-21

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Title

IDENTIFICATION AND DISCOVERY OF NOVEL MICRORNAS IN THE HUMAN GENOME

Author(s)

DOKANEHIIFARD SADAT | MOHAMMAD SOLTANI BAHRAM | Issue Writer Certificate

Keywords

MIRNAQ1

MIRNA TARGET GENESQ2

BIOINFORMATICSQ2

Abstract

Although more than 98% of the human genome is transcribed, most of these transcripts are not translated into proteins. Rather, they are considered as non-coding RNAs.MicroRNAs (MIRNAs) are very short non-coding RNAs approximately 22 nucleotides in length which regulate many key processes of cells such as growth, proliferation, differentiation, cell cycle, apoptosis (programmed cell death) and metabolism. On the other hand, it is known that these small regulatory molecules are involved in many human diseases such as different cancers and cardiovascular disorders. Therefore, discovery and functional characterization of novel MIRNAs is a prominent achievement. Low abundance and spatiotemporal expression of these mediator molecules make their discovery difficult by conventional methods. Therefore, BIOINFORMATICS software have been designed for the prediction of stem-loop structures capable of producing MIRNA precursors in the human genome. On the other hand, there are several BIOINFORMATICS tools for prediction of MIRNA target genes. Prediction of MIRNA target genes helps to characterize the function of a MIRNA. In this paper, we have reviewed some of the common efficient BIOINFORMATICS tools and experimental approaches used for prediction and identification of the MIRNA genes and their target genes.

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APA: Copy

DOKANEHIIFARD, SADAT, & MOHAMMAD SOLTANI, BAHRAM. (2015). IDENTIFICATION AND DISCOVERY OF NOVEL MICRORNAS IN THE HUMAN GENOME. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 18(1), 1-21. SID. https://sid.ir/paper/81300/en

Vancouver: Copy

DOKANEHIIFARD SADAT, MOHAMMAD SOLTANI BAHRAM. IDENTIFICATION AND DISCOVERY OF NOVEL MICRORNAS IN THE HUMAN GENOME. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2015;18(1):1-21. Available from: https://sid.ir/paper/81300/en

IEEE: Copy

SADAT DOKANEHIIFARD, and BAHRAM MOHAMMAD SOLTANI, “IDENTIFICATION AND DISCOVERY OF NOVEL MICRORNAS IN THE HUMAN GENOME,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 18, no. 1, pp. 1–21, 2015, [Online]. Available: https://sid.ir/paper/81300/en

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