STUDY OF LOADING, CYTOTOXICITY, UPTAKE, AND RELEASE OF CURCUMIN FROM A NOVEL GEMINI SURFACTANT NANOCARRIER

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

RAHIMZADEH MARAL; SADEGHIZADEH MAJID; NAJAFI FARHOOD; ARAB SEYED SHAHRIAR; MOBASHERI HAMID

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Pathobiology Research Year:2016 | Volume:19 | Issue:1 Page(s): 13-27

Download Full-Text

Persian Verion

View:

1,100

Download:

Cites:

Information Journal Paper

Title

STUDY OF LOADING, CYTOTOXICITY, UPTAKE, AND RELEASE OF CURCUMIN FROM A NOVEL GEMINI SURFACTANT NANOCARRIER

Author(s)

Keywords

CURCUMINQ2

ANTI-CANCERQ1

GEMINI SURFACTANTQ1

NANOCARRIERQ1

POLYMERSOMEQ1

Abstract

Objective: Numerous researches have been conducted to comprehend the ANTI-CANCER effects of CURCUMIN (Cu). Although the anti-proliferative properties of Cu on cancerous cells is known, the clinical application of this gold substrate is limited. This limitation is mostly due to low solubility, inefficient bioavailability, rapid metabolism, and improper uptake. In this study, we have synthesized a novel biodegradable GEMINI SURFACTANT (Gs), after which the CURCUMIN (Cu) molecules were encapsulated within the polymer to overcome its physicochemical limitations.Methods: We prepared Gs-Cu nanoparticles by the nano precipitation method. Size and polydispersity index of the nanoparticles were determined by the dynamic light scattering (DLS) technique. The release profile of Cu from the polymer matrix was studied, and the MTT assay and cellular uptake of Gs-Cu on MDA-MB-231 cells were investigated in vitro.Results: The Gs polymer had the capability to form POLYMERSOMEs in an aqueous solution; a narrow size distribution was obtained (PDI≅0.3). The encapsulation efficiency approximated 87%. We observed a sustained release profile due to incorporation of Cu into the polymer matrix. The Gs-Cu complex showed more cytotoxicity compared to free Cu because of the higher rate of cellular internalization.Conclusions: The data indicate that Gs POLYMERSOMEs can be regarded as NANOCARRIERs for hydrophobic CURCUMIN molecules.

Cites

No record.

References

Cite

APA: Copy

RAHIMZADEH, MARAL, SADEGHIZADEH, MAJID, NAJAFI, FARHOOD, ARAB, SEYED SHAHRIAR, & MOBASHERI, HAMID. (2016). STUDY OF LOADING, CYTOTOXICITY, UPTAKE, AND RELEASE OF CURCUMIN FROM A NOVEL GEMINI SURFACTANT NANOCARRIER. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 19(1), 13-27. SID. https://sid.ir/paper/81353/en

Vancouver: Copy

RAHIMZADEH MARAL, SADEGHIZADEH MAJID, NAJAFI FARHOOD, ARAB SEYED SHAHRIAR, MOBASHERI HAMID. STUDY OF LOADING, CYTOTOXICITY, UPTAKE, AND RELEASE OF CURCUMIN FROM A NOVEL GEMINI SURFACTANT NANOCARRIER. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2016;19(1):13-27. Available from: https://sid.ir/paper/81353/en

IEEE: Copy

MARAL RAHIMZADEH, MAJID SADEGHIZADEH, FARHOOD NAJAFI, SEYED SHAHRIAR ARAB, and HAMID MOBASHERI, “STUDY OF LOADING, CYTOTOXICITY, UPTAKE, AND RELEASE OF CURCUMIN FROM A NOVEL GEMINI SURFACTANT NANOCARRIER,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 19, no. 1, pp. 13–27, 2016, [Online]. Available: https://sid.ir/paper/81353/en

Related Journal Papers