MORPHOMETRIC CHANGES OF RAT TESTIS AFTER SUBCHRONIC OAL LEAD INTOXICATION AND D-PENICILLAMINE TREATMENT

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ROUSHANDEL D.; KALAVI M.; GHAFARI SORAYA; GHARAVI MOHAMMAD; ROUSHANDEL GH.R.; GOL ALIPOUR M.J.

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Journal: Anatomical Sciences Journal Year:2005 | Volume:3 | Issue:3 Page(s): 203-211

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Title

MORPHOMETRIC CHANGES OF RAT TESTIS AFTER SUBCHRONIC OAL LEAD INTOXICATION AND D-PENICILLAMINE TREATMENT

Author(s)

Keywords

LEAD TOXICITYQ3

TESTISQ3

RECOVERYQ2

D-PENICILLAMINEQ4

RATQ3

Abstract

Purpose: The aim of this study was to assess the efficacy of D-PENICILLAMINE in reducing lead induced morphometric changes in RAT TESTIS.Materials and Methods: Male adult RATs were exposed to 0.4% lead acetate in drinking water for 8 weeks. After this period, 6 RATs sacrificed and testes were removed to evaluate the effects of lead intoxication. The remained lead exposed RATs were divided into two groups: one group received distilled water and the other group received 25-35 mg/kg/day of oral D-p treatment for six weeks, after one week of RECOVERY. TESTIS morphometric changes were studied in H&E stained sections.Results: Width of germinal epithelium and number of sertoli cells were decreased after 8 weeks of lead intoxication (P<0.05). These parameters were still significantly lower than control group after both of RECOVERY and treatment periods (P<0.05).Conclusion: This study showed that subchronic oral lead intoxication induces some changes in adult TESTIS which are not reversible even after D-P administration.

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APA: Copy

ROUSHANDEL, D., KALAVI, M., GHAFARI, SORAYA, GHARAVI, MOHAMMAD, ROUSHANDEL, GH.R., & GOL ALIPOUR, M.J.. (2005). MORPHOMETRIC CHANGES OF RAT TESTIS AFTER SUBCHRONIC OAL LEAD INTOXICATION AND D-PENICILLAMINE TREATMENT. JOURNAL OF IRANIAN ANATOMICAL SCIENCES, 3(3), 203-211. SID. https://sid.ir/paper/81433/en

Vancouver: Copy

ROUSHANDEL D., KALAVI M., GHAFARI SORAYA, GHARAVI MOHAMMAD, ROUSHANDEL GH.R., GOL ALIPOUR M.J.. MORPHOMETRIC CHANGES OF RAT TESTIS AFTER SUBCHRONIC OAL LEAD INTOXICATION AND D-PENICILLAMINE TREATMENT. JOURNAL OF IRANIAN ANATOMICAL SCIENCES[Internet]. 2005;3(3):203-211. Available from: https://sid.ir/paper/81433/en

IEEE: Copy

D. ROUSHANDEL, M. KALAVI, SORAYA GHAFARI, MOHAMMAD GHARAVI, GH.R. ROUSHANDEL, and M.J. GOL ALIPOUR, “MORPHOMETRIC CHANGES OF RAT TESTIS AFTER SUBCHRONIC OAL LEAD INTOXICATION AND D-PENICILLAMINE TREATMENT,” JOURNAL OF IRANIAN ANATOMICAL SCIENCES, vol. 3, no. 3, pp. 203–211, 2005, [Online]. Available: https://sid.ir/paper/81433/en

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