EVALUATION OF PROLIFERATIVE ACTIVITY OF ADULT MOUSE MALE GERM CELLS FOLLOWING ADMINISTRATION OF DIFFERENT DOSES OF NICOTINE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHAJEH JAHROMI S.; MOHAMMAD GHASEMI F.; HAJIZADEH FALLAH H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Anatomical Sciences Journal Year:2011 | Volume:9 | Issue:36 Page(s): 229-240

Download Full-Text

Persian Verion

View:

746

Download:

Cites:

Information Journal Paper

Title

EVALUATION OF PROLIFERATIVE ACTIVITY OF ADULT MOUSE MALE GERM CELLS FOLLOWING ADMINISTRATION OF DIFFERENT DOSES OF NICOTINE

Author(s)

KHAJEH JAHROMI S. | MOHAMMAD GHASEMI F. | HAJIZADEH FALLAH H. | Issue Writer Certificate

Keywords

NICOTINEQ3

PROLIFERATIONQ3

TESTISQ3

SPERMATOGENESIS QUALITYQ2

Abstract

Purpose: NICOTINE can induce sub fertility or infertility both in males and females. The aim of this study is to evaluate the proliferative activity of adult mouse male germ cells following treatment with different doses of NICOTINE.Materials and Methods: Adult male NMRI mice were divided into four groups. The control group received normal saline and the other animals in groups of 2, 3 and 4 were treated with NICOTINE in doses of 0.1, 0.2 and 0.4 mg/Kg, respectively.NICOTINE was administered intraperitoneally once a day for 14 days. All animals were dissected on 15th day, and evaluations were made by Ki67 immunohistochemistry staining and Johnson’s scoring for assessment of proliferative activity of mitotic & meiotic spermatogenic cells and evaluation of quality of spermatogenesis respectively, and Elisa test for serum testosterone level.Statistical analyses were performed using ANOVA and Tukey tests.Results: NICOTINE in doses of 0.2 mg/Kg and 0.4 mg/Kg significantly reduced Johnson's score in comparison with that of control group (p<0.05).NICOTINE in dose of 0.2 and 0.4 mg/Kg significantly reduced ki67 index in meiotic leptotene and pachytene cells in comparison with that of control group.However it was not effective on spermatogonia cells. Serum levels of testosterone in groups of 3 and 4 were significantly reduced compared to that of control group (p<0.05).Conclusion: This study indicates that NICOTINE has adverse effects on spermatogenesis process and it acts in a dose dependent manner. However, in lower doses, proliferative activity is not altered; therefore, it seems that probablility of the other mechanisms are involved in reducing of maturity and quality of spermatogenesis.

Cites

No record.

References

No record.

Cite

APA: Copy

KHAJEH JAHROMI, S., MOHAMMAD GHASEMI, F., & HAJIZADEH FALLAH, H.. (2011). EVALUATION OF PROLIFERATIVE ACTIVITY OF ADULT MOUSE MALE GERM CELLS FOLLOWING ADMINISTRATION OF DIFFERENT DOSES OF NICOTINE. JOURNAL OF IRANIAN ANATOMICAL SCIENCES, 9(36), 229-240. SID. https://sid.ir/paper/81440/en

Vancouver: Copy

KHAJEH JAHROMI S., MOHAMMAD GHASEMI F., HAJIZADEH FALLAH H.. EVALUATION OF PROLIFERATIVE ACTIVITY OF ADULT MOUSE MALE GERM CELLS FOLLOWING ADMINISTRATION OF DIFFERENT DOSES OF NICOTINE. JOURNAL OF IRANIAN ANATOMICAL SCIENCES[Internet]. 2011;9(36):229-240. Available from: https://sid.ir/paper/81440/en

IEEE: Copy

S. KHAJEH JAHROMI, F. MOHAMMAD GHASEMI, and H. HAJIZADEH FALLAH, “EVALUATION OF PROLIFERATIVE ACTIVITY OF ADULT MOUSE MALE GERM CELLS FOLLOWING ADMINISTRATION OF DIFFERENT DOSES OF NICOTINE,” JOURNAL OF IRANIAN ANATOMICAL SCIENCES, vol. 9, no. 36, pp. 229–240, 2011, [Online]. Available: https://sid.ir/paper/81440/en

Related Journal Papers