PROGNOSTIC VALUE OF THE RELATIONSHIP BETWEEN SERUM LEVELS OF INTERLEUKIN-6 AND CLINICAL OUTCOME IN PATIENTS WITH SEVERE HEAD INJURY

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YOUSEFZADEH SHAHROKH; DEHNADI MOGHADAM ANOOSH; KAZEMNEZHAD LEILI EHSAN; HOSEINPOUR MARIEH; SANEEI ZAHRA; MOHTASHAM AMIRI ZAHRA

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Journal: Journal of Sabzevar University of Medical Sciences Year:2014 | Volume:21 | Issue:3 Page(s): 485-491

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Title

PROGNOSTIC VALUE OF THE RELATIONSHIP BETWEEN SERUM LEVELS OF INTERLEUKIN-6 AND CLINICAL OUTCOME IN PATIENTS WITH SEVERE HEAD INJURY

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Keywords

TRAUMATIC BRAIN INJURYQ2

INTERLEUKIN-6Q2

NEUROLOGICAL INFLAMMATIONQ2

CLINICAL OUTCOMEQ2

Abstract

Background: Damage caused by TRAUMATIC BRAIN INJURY (TBI) depends on the extent of primary and secondary damages. The latter can cause induced NEUROLOGICAL INFLAMMATION by releasing pro- and anti-inflammatory cytokines and chemokines.Measurement of serum INTERLEUKIN-6 (IL-6), as a pro-inflammatory cytokine, can be useful in predicting outcome in patients with TBI.Materials & Methods: In a cross-sectional study, 44 patients with GCS≤8 (Glasgow Coma Scale) and age ³ 14 years, hospitalized in Poursina teaching hospital, were included in the study. Blood samples were collected from patients in the first 6 hours after the accident; and serum was tested by ELISA method for the determination of IL-6 levels. Patients' outcomes were recorded 6 months after head injury according to Glasgow Outcome Scale (GOS), and were divided in two good (GOS ≥4) and bad (GOS<3) outcome groups. Data were analyzed in SPSS software version18 using the Spearman's rho, independent-t test, Fisher Exact test and Mann-Whitney test.Results: Comparison of IL-6 serum levels, in the two groups after 6 months of head injury, showed that mean serum levels of IL-6 in good outcome group was lower than bad outcome group (85.2±51.6 vs.162.3±141.1, respectively) (P<0.03).Conclusion: Elevated serum levels of IL-6 in patients with severe TBI, is associated with poor CLINICAL OUTCOME.

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APA: Copy

YOUSEFZADEH, SHAHROKH, DEHNADI MOGHADAM, ANOOSH, KAZEMNEZHAD LEILI, EHSAN, HOSEINPOUR, MARIEH, SANEEI, ZAHRA, & MOHTASHAM AMIRI, ZAHRA. (2014). PROGNOSTIC VALUE OF THE RELATIONSHIP BETWEEN SERUM LEVELS OF INTERLEUKIN-6 AND CLINICAL OUTCOME IN PATIENTS WITH SEVERE HEAD INJURY. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 21(3), 485-491. SID. https://sid.ir/paper/82064/en

Vancouver: Copy

YOUSEFZADEH SHAHROKH, DEHNADI MOGHADAM ANOOSH, KAZEMNEZHAD LEILI EHSAN, HOSEINPOUR MARIEH, SANEEI ZAHRA, MOHTASHAM AMIRI ZAHRA. PROGNOSTIC VALUE OF THE RELATIONSHIP BETWEEN SERUM LEVELS OF INTERLEUKIN-6 AND CLINICAL OUTCOME IN PATIENTS WITH SEVERE HEAD INJURY. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;21(3):485-491. Available from: https://sid.ir/paper/82064/en

IEEE: Copy

SHAHROKH YOUSEFZADEH, ANOOSH DEHNADI MOGHADAM, EHSAN KAZEMNEZHAD LEILI, MARIEH HOSEINPOUR, ZAHRA SANEEI, and ZAHRA MOHTASHAM AMIRI, “PROGNOSTIC VALUE OF THE RELATIONSHIP BETWEEN SERUM LEVELS OF INTERLEUKIN-6 AND CLINICAL OUTCOME IN PATIENTS WITH SEVERE HEAD INJURY,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 3, pp. 485–491, 2014, [Online]. Available: https://sid.ir/paper/82064/en

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